Epigenetic and genetic alterations have long been thought of as two separate mechanisms
participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands …

Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical
properties. Despite advances in surgical techniques and clinical regimens, treatment of high …

We report that tumor cells without mitochondrial DNA (mtDNA) show delayed tumor growth,
and that tumor formation is associated with acquisition of mtDNA from host cells. This leads …

Human aging cannot be fully understood in terms of the constrained genetic setting.
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …

methylcytosine is a major epigenetic modification that is sometimes called" the fifth
nucleotide." However, our knowledge of how offspring inherit the DNA methylome from …

The discovery of cytosine hydroxymethylation (5hmC) suggested a simple means of
demethylating DNA and activating genes. Further experiments, however, unearthed an …

Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …

Genome-wide erasure of DNA cytosine-5 methylation has been reported to occur along the
paternal pronucleus in fertilized oocytes in an apparently replication-independent manner …

Nucleic acids carry a wide range of different chemical modifications. In contrast to previous
views that these modifications are static and only play fine-tuning functions, recent research …

A complex interplay between multiple biological effects shapes the aging process. The
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …