The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …

Lithium is a well-established therapeutic option for the acute and long-term management of
bipolar disorder and major depression. More recently, based on findings from translational …

For more than 60 years, the mood stabilizer lithium has been used alone or in combination
for the treatment of bipolar disorder, schizophrenia, depression, and other mental illnesses …

Background Bipolar disorder phenomenologically is a biphasic disorder of energy
availability; increased in mania and decreased in depression. In consort, there is …

The canonical Wnt signaling pathway is critical for development of the mammalian central
nervous system and regulates diverse processes throughout adulthood, including adult …

Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%,
the effective treatment, and prevention of bipolar disorder represents an area of significant …

In this paper, we propose that lithium may exert its therapeutic effect in bipolar disorder by
acting on insulin signaling pathways. Specifically, we assess the importance of the …

The mood disorders major depressive disorder and bipolar disorder are prevalent, are
inadequately treated, and little is known about their etiologies. A better understanding of the …

Brain dopamine receptors have been preferred targets for numerous pharmacological
compounds developed for the treatment of various neuropsychiatric disorders. Recent …

Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are
projected to lead global disease burden within the next decade. Pharmacotherapy, the …