Developmental origins of metabolic diseases
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …
as obese, while nearly one-third of children globally experience poor growth and …
Epigenetic responses and the developmental origins of health and disease
D Goyal, SW Limesand, R Goyal - Journal of Endocrinology, 2019 - joe.bioscientifica.com
Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …
successful postnatal life. Based on the stressors during gestation, the pregnant female …
Children born small for gestational age: differential diagnosis, molecular genetic evaluation, and implications
MJJ Finken, M van der Steen, CCJ Smeets… - Endocrine …, 2018 - academic.oup.com
Children born small for gestational age (SGA), defined as a birth weight and/or length
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …
Daily injection of the β2 adrenergic agonist clenbuterol improved poor muscle growth and body composition in lambs following heat stress-induced intrauterine growth …
RL Gibbs, RM Swanson, JK Beard, ZM Hicks… - Frontiers in …, 2023 - frontiersin.org
Background: Intrauterine growth restriction (IUGR) is associated with reduced β2 adrenergic
sensitivity, which contributes to poor postnatal muscle growth. The objective of this study …
sensitivity, which contributes to poor postnatal muscle growth. The objective of this study …
Dousing the flame: reviewing the mechanisms of inflammatory programming during stress-induced intrauterine growth restriction and the potential for ω-3 …
MR White, DT Yates - Frontiers in Physiology, 2023 - frontiersin.org
Intrauterine growth restriction (IUGR) arises when maternal stressors coincide with peak
placental development, leading to placental insufficiency. When the expanding nutrient …
placental development, leading to placental insufficiency. When the expanding nutrient …
Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism
Compelling epidemiological and animal experimental data demonstrate that
cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine …
cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine …
Perinatal nutritional and metabolic pathways: early origins of chronic lung diseases
C Kuiper-Makris, J Selle, E Nüsken, J Dötsch… - Frontiers in …, 2021 - frontiersin.org
Lung development is not completed at birth, but expands beyond infancy, rendering the lung
highly susceptible to injury. Exposure to various influences during a critical window of organ …
highly susceptible to injury. Exposure to various influences during a critical window of organ …
Going up inflame: reviewing the underexplored role of inflammatory programming in stress-induced intrauterine growth restricted livestock
ZM Hicks, DT Yates - Frontiers in Animal Science, 2021 - frontiersin.org
The impact of intrauterine growth restriction (IUGR) on health in humans is well-recognized.
It is the second leading cause of perinatal mortality worldwide, and it is associated with …
It is the second leading cause of perinatal mortality worldwide, and it is associated with …
Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal β cells
Summary tRNA-derived fragments (tRFs) are an emerging class of small non-coding RNAs
with distinct cellular functions. Here, we studied the contribution of tRFs to the regulation of …
with distinct cellular functions. Here, we studied the contribution of tRFs to the regulation of …
Maternal low-protein diet on the last week of pregnancy contributes to insulin resistance and β-cell dysfunction in the mouse offspring
Maternal low-protein diet (LP) throughout gestation affects pancreatic β-cell fraction of the
offspring at birth, thus increasing their susceptibility to metabolic dysfunction and type 2 …
offspring at birth, thus increasing their susceptibility to metabolic dysfunction and type 2 …