Humans and wildlife are exposed to an intractably large number of different combinations of
chemicals via food, water, air, consumer products, and other media and sources. This raises …

High-content screening (HCS) technology combining automated microscopy and
quantitative image analysis can address biological questions in academia and the …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

In this project we set up a human cell‐based DNTin vitro testing strategy that is based on test
methods with high readiness and data generated therefrom. The methods underwent afit‐for …

Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human
exposome. However, DNT data from animal studies are available for only a small …

Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine
receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of …

Read-across (RAx) translates available information from well-characterized chemicals to a
substance for which there is a toxicological data gap. The OECD is working on case studies …

Neonicotinoid pesticides, originally developed to target the insect nervous system, have
been reported to interact with human receptors and to activate rodent neurons. Therefore …

In many industrial sectors, there is a need for reliable ways to evaluate the safety of
chemicals with methods anchored to human biology and pathology. For this purpose, many …

Due to their neurodevelopmental toxicity, flame retardants (FRs) like polybrominated
diphenyl ethers are banned from the market and replaced by alternative FRs, like …