A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic,
permeable barrier allowing for selective absorption of nutrients, while restricting access to …

Airway epithelial cells form a barrier to the outside world and are at the front line of mucosal
immunity. Epithelial apical junctional complexes are multiprotein subunits that promote cell …

Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion,
tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of …

Mucosal barriers separate self from non-self and are essential for life. These barriers, which
are the first line of defense against external pathogens, are formed by epithelial cells and the …

The gut mucosa is constantly challenged by a bombardment of foreign antigens and
environmental microorganisms. As such, the precise regulation of the intestinal barrier …

The intestinal epithelium forms a key protective barrier that separates internal organs from
the harmful environment of the gut lumen. Increased permeability of the gut barrier is a …

Inflammatory bowel disease (IBD) is a multifactorial disease. A breach in the mucosal
barrier, otherwise known as “leaky gut,” is alleged to promote mucosal inflammation by …

Inflammation has long been suspected to play a major role in the pathogenesis of cancer.
Only recently, however, have some mechanisms of its tumor promoting effects become …

Abstract p120 catenin is the best studied member of a subfamily of proteins that associate
with the cadherin juxtamembrane domain to suppress cadherin endocytosis. p120 also …