Defects in the development or maintenance of tubule diameter correlate with polycystic
kidney disease. Here, we report that absence of the cadherin regulator p120 catenin …

P120-catenin is essential to vertebrate development, modulating cadherin and small-
GTPase functions, and growing evidence points also to roles in the nucleus. A complexity in …

The adenomatous polyposis coli (APC) tumor suppressor protein is associated with the
regulation of Wnt signaling; however, APC also controls other cellular processes including …

The cells of the intestinal epithelium provide a selectively permeable barrier between the
external environment and internal tissues. The integrity of this barrier is maintained by tight …

In vertebrate epithelia, p120-catenin (hereafter referred to as p120; also known as CTNND1)
mediates E-cadherin stability and suppression of RhoA. Genetic ablation of p120 in various …

Constitutive Wnt/β-catenin signaling is a key contributor to colorectal cancer (CRC).
Although inactivation of the tumor suppressor adenomatous polyposis coli (APC) is …

Inflammatory bowel disease (IBD) is characterized by chronic inflammation along the
gastrointestinal tract. For IBD effective treatment, developing an orally administered stable …

Since its discovery in 1989 as a substrate of the Src oncogene, p120catenin has been
revealed as an important player in cancer initiation and tumour dissemination. p120catenin …

p120 loss destabilizes E-cadherin and could therefore result in tumor and/or metastasis-
promoting activities similar to those caused by E-cadherin downregulation. Previously, we …

Although p120-catenin (p120) is crucial for E-cadherin function, ablation experiments in
epithelial tissues from different organ systems reveal markedly different effects. Here, we …