Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity

Y Jin, D Ibrahim, ST Magness… - American Journal of …, 2018 - journals.physiology.org
Adherens junctions (AJs), together with tight junctions (TJs), form an apical junctional
complex that regulates intestinal epithelial cell-to-cell adherence and barrier homeostasis …

Intestinal and Mucosal Microbiome Response to Oral Challenge of Enterotoxigenic Escherichia coli in Weaned Pigs

SS Peng, Y Li, Q Chen, Q Hu, Y He, L Che, PP Jiang - Pathogens, 2022 - mdpi.com
Enterotoxigenic Escherichia coli (ETEC) is closely associated with diarrhoea in children in
resource-limited countries. This study aims to investigate the change of the mucosal …

Expressions of E-cadherin, p120ctn, β-catenin and NF-κB in ulcerative colitis

C Zhang, L Liu, W Sun, S Qin, L Qin, X Wang - Journal of Huazhong …, 2015 - Springer
This study was aimed to investigate the expressions of E-cadherin, p120ctn, β-catenin and
NF-κB in ulcerative colitis (UC) tissues and the implications of their expressions in the …

Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells

H Tian, E Sanders, A Reynolds… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: Development of the ocular anterior segment depends largely on periocular
mesenchyme cells, which are derived predominantly from neural crest cells (NCC). Specific …

Differential expression of p120-catenin 1 and 3 isoforms in epithelial tissues

JH Venhuizen, S Sommer, PN Span, P Friedl… - Scientific reports, 2019 - nature.com
Abstract P120 catenin (p120) is a non-redundant master regulatory protein of cadherin-
based cell-cell junctions, intracellular signaling, and tissue homeostasis and repair …

Trpm7 protein contributes to intercellular junction formation in mouse urothelium

M Watanabe, Y Suzuki, K Uchida, N Miyazaki… - Journal of Biological …, 2015 - ASBMB
Trpm7 is a divalent cation-permeable channel that has been reported to be involved in
magnesium homeostasis as well as cellular adhesion and migration. We generated …

Enterocytic differentiation is modulated by lipid rafts-dependent assembly of adherens junctions

NT Chartier, MG Lainé, B Ducarouge, C Oddou… - Experimental cell …, 2011 - Elsevier
Integrity of the epithelial barrier is determined by apical junctional complexes which also
participate in the signalling pathways inducing intestinal cell differentiation. Lipid rafts (LR) …

Kaiso-induced intestinal inflammation is preceded by diminished E-cadherin expression and intestinal integrity

SC Robinson, R Chaudhary, R Jiménez-Saiz… - PLoS …, 2019 - journals.plos.org
Chronic intestinal inflammation contributes to pathologies such as inflammatory bowel
disease (IBD) and colon cancer. While the precise etiology remains controversial, IBD is …

Leukocyte–epithelial interactions and mucosal homeostasis

JD Matthews, CM Weight… - Toxicologic pathology, 2014 - journals.sagepub.com
Many common inflammatory disorders are characterized by the infiltration of neutrophils
across epithelial lined (mucosal) surfaces resulting in disruption of critical barrier function …

The role of immune and epithelial stem cells in inflammatory bowel disease therapy

A Binienda, S Ziolkowska, IH Hauge… - Current Drug …, 2020 - ingentaconnect.com
Background: Inflammatory Bowel Disease (IBD) is categorized as Crohn's disease (CD) and
Ulcerative colitis (UC) and is characterized by chronic inflammation in the gastrointestinal …