[HTML][HTML] Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix

J Jia, J Chen, G Wang, M Li, Q Zheng, D Li - Biomedicine & …, 2023 - Elsevier
The traditional Chinese medicine (TCM) Rehmanniae Radix (RR) refers to the fresh or dried
root tuber of the plant Rehmannia glutinosa Libosch of the family Scrophulariaceae. As a …

[HTML][HTML] Rgl-exomiR-7972, a novel plant exosomal microRNA derived from fresh Rehmanniae Radix, ameliorated lipopolysaccharide-induced acute lung injury and …

FS Qiu, JF Wang, MY Guo, XJ Li, CY Shi, F Wu… - Biomedicine & …, 2023 - Elsevier
Plant-derived exosome-like nanoparticles (ELNs) have been proposed as a novel
therapeutic tool for preventing human diseases. However, the number of well-verified plant …

[HTML][HTML] Protective effects of catalpol on cardio-cerebrovascular diseases: A comprehensive review

Z Zhang, Y Dai, Y Xiao, Q Liu - Journal of Pharmaceutical Analysis, 2023 - Elsevier
Catalpol, an iridoid glucoside isolated from Rehmannia glutinosa, has gained attention due
to its potential use in treating cardio-cerebrovascular diseases (CVDs). This extensive …

Catalpol attenuates oxidative stress and inflammation via mechanisms involving sirtuin-1 activation and NF-κB inhibition in experimentally-induced chronic kidney …

NE Zaaba, S Al-Salam, S Beegam, O Elzaki, J Yasin… - Nutrients, 2023 - mdpi.com
Chronic kidney disease (CKD) is a stealthy disease, and its development is linked to
mechanisms including inflammation and oxidative stress. Catalpol (CAT), an iridoid …

Air pollution induces pyroptosis of human monocytes through activation of inflammasomes and Caspase-3-dependent pathways

A Gałuszka-Bulaga, K Tkacz, K Węglarczyk… - Journal of …, 2023 - Springer
Abstract According to the World Health Organization (WHO), air pollution is one of the most
serious threats for our planet. Despite a growing public awareness of the harmful effects of …

Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H] Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the …

X Ge, Y Zheng, Y He, C Chen, C Yang… - Current Drug …, 2023 - ingentaconnect.com
Background: Catalpol, one of the main bioactive components isolated from Rehmannia
glutinosa, was developed by Suzhou Youseen for the treatment of ischemic stroke; however …

Transcriptional response of blood mononuclear cells from patients with inflammatory and autoimmune disorders exposed to “Krakow smog”

A Gałuszka-Bulaga, J Hajto, M Borczyk, S Gołda… - Cells, 2022 - mdpi.com
Despite the general awareness of the need to reduce air pollution, the efforts were
undertaken in Poland to eliminate the pollutants and their harmful effect on human health …

Palliative effects of carnosol on lung‐deposited pollutant particles‐induced thrombogenicity and vascular injury in mice

S Beegam, NE Zaaba, O Elzaki… - Pharmacology …, 2024 - Wiley Online Library
The toxicity of inhaled particulate air pollution perseveres even at lower concentrations than
those of the existing air quality limit. Therefore, the identification of safe and effective …

[HTML][HTML] Evaluation antioxidant and anti-inflammatory activity of ethanolic extracts of myriophyllum spicatum L. in lipopolysaccharide-stimulated RAW 264.7 cells

CH Kim, YK Lee, MJ Kim, JS Choi, BS Hwang… - Korean Journal of Plant …, 2023 - kjpr.kr
Myriophyllum spicatum L. has been used as an ornamental in ponds and aquariums, and as
a folk remedy for inflammation and pus. Nevertheless, the biological activity and underlying …

[PDF][PDF] and Biochemistry

NE Zaabaa, S Beegama, O Elzakia… - Cell Physiol …, 2024 - cellphysiolbiochem.com
Abstract Background/Aims: Inhaled particulate air pollution is associated with cardiotoxicity
with underlying mechanisms including oxidative stress and inflammation. Carnosol …