Next-generation sequencing technologies have begun to revolutionize the field of cancer
genetics through rapid and accurate assessment of a patient's DNA makeup with minimal …

The disclosure of incidental findings, also called unsolicited findings, unexpected results,
and secondary variants, is increasingly recognised as an issue in clinical and research …

Cancer patients participating in studies involving experimental or diagnostic next-generation
sequencing (NGS) procedures are confronted with the possibility of unsolicited findings. The …

As a matter of respect for the person, it is considered an ethical duty to offer to return
research results to participants where appropriate. Nevertheless, the return of individual …

The unknown nature of tomorrow's research makes informed consent in biobank research a
challenge. Whether the consent given by biobank participants is 'broad'or 'narrow', the ever …

Background Due to decreasing cost, and increasing speed and precision, genomic
sequencing in research is resulting in the generation of vast amounts of genetic data. The …

Incidental findings (IFs) are acknowledged to be among the most important ethical issues to
consider in biobank research. Genome-wide association studies and disease-specific …

One goal of human genetics is to understand the genetic basis of disease, a challenge for
diseases of complex inheritance because risk alleles are few relative to the vast set of …

Diagnostic uncertainties are intricately associated with genomic testing—especially
concerning new technologies such as exome sequencing—with test results being either …

The potential for next generation sequencing research (NGS) to generate individual genetic
results could have implications for the informed consent process and the provision of genetic …