[HTML][HTML] Anti-asthmatic fraction screening and mechanisms prediction of Schisandrae Sphenantherae Fructus based on a combined approach
F Li, B Li, J Liu, X Wei, T Qiang, X Mu… - Frontiers in …, 2022 - frontiersin.org
Objective: Schisandrae Sphenantherae Fructus (SSF) is a traditional Chinese medicine
used to treat coughs and pulmonary inflammatory diseases. However, the …
used to treat coughs and pulmonary inflammatory diseases. However, the …
VEGF pathway gene expression profile of proliferating versus involuting infantile hemangiomas: Preliminary evidence and review of the literature
Background. Infantile hemangiomas may have unexpected behavior. Initial regression
(spontaneously or drug-induced) may be followed by unexplained recurrences. At this …
(spontaneously or drug-induced) may be followed by unexplained recurrences. At this …
p38MAPK silencing attenuates scar proliferation after cleft palate repair surgery in rats via MRTF-A/SRF pathway
Q Ding, G Wang, L Xue, J Yue, Y Xu, Z Fu… - Experimental Cell …, 2022 - Elsevier
Scarring is the primary factor of maxilla growth restriction among people who have
undergone cleft palate repair surgery. p38 mitogen-activated protein kinase (p38MAPK) …
undergone cleft palate repair surgery. p38 mitogen-activated protein kinase (p38MAPK) …
Uncovering the Nephroprotective Mechanism of Caffeic Acid in Renal Tubulointerstitial Fibrosis through Network Pharmacology Analysis
W Sun, H Liu, B Wu, L Dai, Y Ren… - Natural Product …, 2024 - journals.sagepub.com
Background: Renal tubulointerstitial fibrosis (RTF) is a progressive kidney condition
characterized by the formation of fibrotic tissue. Caffeic acid (CA), a key component of the …
characterized by the formation of fibrotic tissue. Caffeic acid (CA), a key component of the …
Exploring the Mechanisms of the Huangqin Qingfei Decoction in Pneumonia Treatment for Lipopolysaccharide-Induced Mouse Model: A Network Pharmacology …
Z Zheng, J Lei, J Chang, X Yi… - Natural Product …, 2024 - journals.sagepub.com
Objective: In this study, a network pharmacological approach, and in vivo validation
experiments were used to screen the active components of the Huangqin Qingfei decoction …
experiments were used to screen the active components of the Huangqin Qingfei decoction …
[HTML][HTML] Affordable amino acid α/β-deuteration and specific labeling for NMR signal enhancement: Evaluation on the kinase p38α
R Ghouil, C Bouguechtouli, H Chérot, A Marcelot… - Journal of Magnetic …, 2023 - Elsevier
Although very effective in decreasing NMR relaxation of large proteins, homogeneous
deuteration can be costly, and anyway unsuitable for recombinant production in metazoan …
deuteration can be costly, and anyway unsuitable for recombinant production in metazoan …
Machine learning assisted discovery of novel p38α inhibitors from natural products
T Shen, Y Tao, B Liu, D Kong… - … Chemistry & High …, 2023 - ingentaconnect.com
Background: P38α, emerging as a hot spot for drug discovery, is a member of the mitogen-
activated protein kinase (MAPK) family and plays a crucial role in regulating the production …
activated protein kinase (MAPK) family and plays a crucial role in regulating the production …
Identification of the TF-miRNA-mRNA co-regulatory networks involved in sepsis
X Luo, W Lu, J Zhao, J Hu, E Chen, S Fu… - Functional & Integrative …, 2022 - Springer
Sepsis is a life-threatening medical condition caused by a dysregulated host response to
infection. Recent studies have found that the expression of miRNAs is associated with the …
infection. Recent studies have found that the expression of miRNAs is associated with the …
Structural controllability to unveil hidden regulation mechanisms in Unfolded Protein Response: The role of network models
Abstract The Unfolded Protein Response is the cell mechanism for maintaining the balance
of properly folded proteins in the endoplasmic reticulum, the specialized cellular …
of properly folded proteins in the endoplasmic reticulum, the specialized cellular …
Signature pattern of gene expression and signaling pathway in premature diabetic patients uncover their correlation to early age coronary heart disease
S Ahmadloo, KH Ling, A Fazli, G Larijani… - Diabetology & Metabolic …, 2022 - Springer
Abstract Background Coronary Heart Disease (CHD) is the leading cause of death in
industrialized countries. There is currently no direct relation between CHD and type 2 …
industrialized countries. There is currently no direct relation between CHD and type 2 …