[PDF][PDF] Exploring the mechanism of physcion-1-O-β-D-monoglucoside against acute lymphoblastic leukaemia based on network pharmacology and experimental …

J Liu, Y Yang, Y Zeng, X Qin, L Guo, W Liu - Heliyon, 2023 - cell.com
Objective To explore the mechanism of PG against acute lymphoblastic leukaemia (ALL) by
network pharmacology and experimental verification in vitro. Methods First, the biological …

Expression and functional analysis of miR-665 in bovine mammary epithelial cell inflammation

Y LI, X WANG, J YANG, Z LUORENG… - Biotechnology …, 2022 - biotech.aiijournal.com
In order to explore the expression and function of miR-665 in bovine mammary epithelial cell
inflammation, lipopolysaccharide (LPS) was used to induce bovine mammary epithelial cell …

A Network Pharmacology to Explore the Potential Targets of Canagliflozin and Dapagliflozin in Treating Atherosclerosis

J Wang, D Li, W Ju, H Wang - Journal of Vascular Diseases, 2022 - mdpi.com
Background: Atherosclerosis (AS) is an important pathological basis of many cardiovascular
diseases. Canagliflozin and dapagliflozin have yielded impressive results in the treatment of …

Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways

HE Kızıl, C Caglayan, E Darendelioğlu, A Ayna, C Gür… - 2022 - researchsquare.com
Background Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-
metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive …

Microsporidia Ser/Thr Protein Phosphatase PP1 Targets DCs MAPK Pathway and Impairs Immune Functions

J Bao, Y Tang, Y Chen, J Jin, X Wang, G An, L Cao… - bioRxiv, 2023 - biorxiv.org
Microsporidia are difficult to completely eliminate. Their persistence may disrupt host cell
functions. Here in this study, we aimed to elucidate the impairing effects and consequences …

[HTML][HTML] 复元活血汤治疗III 型前列腺炎的网络药理学研究

母友友, 谢红, 张烽, 李慧君, 刘云路, 申军 - Pharmacy Information, 2023 - hanspub.org
目的: 通过网络药理学方法探讨复元活血汤治疗III 型前列腺炎的作用机制. 方法:
使用中药系统药理学分析平台(TCMSP) 获取复元活血汤的活性成分及药物靶点, 从GeneCards …

[HTML][HTML] Study on the mechanism of Wumei San in treating piglet diarrhea using network pharmacology and molecular docking

H Yin, W Liu, X Ji, G Yan, X Zeng, W Zhao… - Frontiers in Veterinary …, 2023 - frontiersin.org
Wumei San (WMS) is a traditional Chinese medicine that has been widely applied in the
treatment of piglet diarrhea (PD). However, the mechanism of WMS in PD has not been …

p38 mitogen‐activated protein kinase: Functions and targeted therapy in diseases

Q Zheng, S Li, A Wang, M Zhe, P Yang… - MedComm …, 2023 - Wiley Online Library
P38 mitogen‐activated protein kinase (p38MAPK) is a multifunctional protein kinase that
plays an important role in human normal physiological activities and a variety of major …

Evaluation of the Inhibitory Effects of Pyridylpyrazole Derivatives on LPS-Induced PGE2 Productions and Nitric Oxide in Murine RAW 264.7 Macrophages

MM Gamal El-Din, MI El-Gamal, YD Kwon, SY Kim… - Molecules, 2021 - mdpi.com
A series of thirteen triarylpyrazole analogs were investigated as inhibitors of
lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2) and nitric oxide (NO) production …

Honokiol inhibits the inflammatory response and lipid metabolism disorder by inhibiting p38α in alcoholic liver disease

C Yang, Y Zhao, Z Luo, Y Hu, S Wang, S Hu… - Planta …, 2023 - thieme-connect.com
Alcoholic liver disease is one of the leading causes of liver-related morbidity and mortality
worldwide, but effective treatments are still lacking. Honokiol, a lignin-type natural …