Transplanting marginal organs in the era of modern machine perfusion and advanced organ monitoring

T Resch, B Cardini, R Oberhuber… - Frontiers in …, 2020 - frontiersin.org
Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …

[HTML][HTML] Protective mechanisms and current clinical evidence of hypothermic oxygenated machine perfusion (HOPE) in preventing post-transplant cholangiopathy

A Schlegel, RJ Porte, P Dutkowski - Journal of Hepatology, 2022 - Elsevier
The development of cholangiopathies after liver transplantation impacts on the quality and
duration of graft and patient survival, contributing to higher costs as numerous interventions …

[HTML][HTML] Observations on the ex situ perfusion of livers for transplantation

CJE Watson, V Kosmoliaptsis, C Pley, L Randle… - American journal of …, 2018 - Elsevier
Normothermic ex situ liver perfusion might allow viability assessment of livers before
transplantation. Perfusion characteristics were studied in 47 liver perfusions, of which 22 …

Transplantation of high-risk donor livers after ex situ resuscitation and assessment using combined hypo-and normothermic machine perfusion: a prospective clinical …

OB van Leeuwen, Y de Vries, M Fujiyoshi… - Annals of …, 2019 - journals.lww.com
Objective: The aim of this study was to evaluate sequential hypothermic and normothermic
machine perfusion (NMP) as a tool to resuscitate and assess viability of initially declined …

Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high‐risk donor livers

OB van Leeuwen, SB Bodewes… - American Journal of …, 2022 - Wiley Online Library
Ex situ normothermic machine perfusion (NMP) is increasingly used for viability assessment
of high‐risk donor livers, whereas dual hypothermic oxygenated machine perfusion …

Biliary bicarbonate, pH, and glucose are suitable biomarkers of biliary viability during ex situ normothermic machine perfusion of human donor livers

APM Matton, Y de Vries, LC Burlage, R van Rijn… - …, 2019 - journals.lww.com
Background. Ex situ normothermic machine perfusion (NMP) can be used to assess viability
of suboptimal donor livers before implantation. Our aim was to assess the diagnostic …

Pretransplant sequential hypo‐and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin‐based oxygen carrier …

Y de Vries, APM Matton, MWN Nijsten… - American journal of …, 2019 - Wiley Online Library
Ex situ dual hypothermic oxygenated machine perfusion (DHOPE) and normothermic
machine perfusion (NMP) of donor livers may have a complementary effect when applied …

Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: A European observational cohort study

IMA Brüggenwirth, M Mueller… - American Journal of …, 2022 - Wiley Online Library
A short period (1–2 h) of hypothermic oxygenated machine perfusion (HOPE) after static
cold storage is safe and reduces ischemia‐reperfusion injury‐related complications after …

Liver transplantation today: where we are now and where we are going

AS Bodzin, TB Baker - Liver Transplantation, 2018 - journals.lww.com
Liver transplantation was made a reality through the bravery, innovation, and persistence of
Dr. Thomas Starzl. His death in 2017, at the age of 90, makes us pause to consider how far …

Clinical implementation of prolonged liver preservation and monitoring through normothermic machine perfusion in liver transplantation

B Cardini, R Oberhuber, M Fodor, T Hautz… - …, 2020 - journals.lww.com
Background. Normothermic machine perfusion (NMP) bears the potential for significant
prolongation of liver preservation before transplantation. Although safety and feasibility have …