Herein, we report the development of a macromolecular multifunctional imaging tool for
biological investigations, which is comprised of an N‐(2‐hydroxypropyl) methacrylamide …

Glutamate carboxypeptidases II and III (GCPII and GCPIII) are highly homologous di-zinc
metallopeptidases belonging to the M28 family. These enzymes are expressed in a variety …

This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first
discovered in 1961. These phages played a unique role in early studies of molecular …

Viral nanoparticles represent potential natural versatile platforms for targeted gene and drug
delivery. Improving the efficiency of gene transfer mediated by viral vectors could not only …

RNA-peptide/protein interactions have been of utmost importance to life since its earliest
forms, reaching even before the last universal common ancestor (LUCA). However, the …

abstract Nanoparticle-based therapeutics have been applied in a broad range of clinical and
preclinical applications from diagnosis to treatment for cancer. A wide range of synthetic and …

The enormous therapeutic potential of selective ribonucleic acid (RNA) interference has
recently been manifested by the approval of several small interfering RNA (siRNA)‐based …

Tato práce se zabývá uspořádáním RTX (" Repeats in ToXin") domén vybraných RTX toxinů
a vlivem těchto struktur především na balení toxinů do nativní struktury jejich sekreci a. Pro …

The aim of this thesis is to reveal the potential of mouse polyomavirus (MPyV) based virus-
like particles (VLPs) as possible nanocarriers for directed delivery of therapeutic or …

Hyaluronic acid (HA) is widely studied as a targeting moiety to CD44 overexpressing cancer
cells. Various types of nanoparticles (NPs) were modified by HA. Virus-like particles (VLPs) …