The transcription of DNA by RNA polymerase occurs as a discontinuous process described
as transcriptional bursting. This bursting behavior is observed across species and has been …

Stochastic models of gene expression are typically formulated using the chemical master
equation, which can be solved exactly or approximately using a repertoire of analytical …

The mRNA life cycle is a complex biochemical process, involving transcription initiation,
elongation, termination, splicing, and degradation. Each of these molecular events is …

We introduce a biologically detailed, stochastic model of gene expression describing the
multiple rate-limiting steps of transcription, nuclear pre-mRNA processing, nuclear mRNA …

Phenotypic switching plays a crucial role in cell fate determination across various
organisms. Recent experimental findings highlight the significance of protein …

Development is characterized by consecutive cell state transitions that build on each other
and ultimately lead to the generation of the numerous different cell types found in the …

Stochastic models of gene expression are typically formulated using the chemical master
equation, which can be solved exactly or approximately using a repertoire of analytical …

Gene expression comprises many asymmetric and complex processes. Transcriptional
details revealed by the whole genome indicate that genes resort to transcriptional bursting …

Single-cell sequencing revealed the transcriptional heterogeneity of neurons and introduced
transcriptome-defined neuron types and subtypes. Temporal recordings of gene …

The stochastic kinetics of transcription can be accurately inferred from the distribution of
nascent RNA. However, the inferences using conventional gene-expression models with …