Optimization of antimicrobial dosing in accordance with pharmacokinetics/
pharmacodynamics targets can improve survival and clinical cure. Dosing regimens for …

Beta-lactams are an important family of antibiotics used to treat infections and are commonly
used in critically ill patients. Optimal use of these drugs in the intensive care unit (ICU) is …

Antimicrobial dosing in the intensive care unit (ICU) can be problematic due to various
challenges including unique physiological changes observed in critically ill patients and the …

The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …

While therapeutic drug monitoring (TDM) that uses blood as the biological matrix is the
traditional gold standard, this practice may be impossible, impractical, or unethical for some …

Introduction: Protein binding can diminish the pharmacological effect of beta-lactam
antibiotics. Only the free fraction has an antibacterial effect. The aim of this systematic …

Critically ill patients admitted to intensive care unit (ICU) with severe infections, or those who
develop nosocomial infections, have poor outcomes with substantial morbidity and mortality …

Introduction Individualizing antibiotic therapy is paramount to improve clinical outcomes
while minimizing the risk of toxicity and antimicrobial therapy. β-lactam antibiotics are …

Elimination of filariasis requires a macrofilaricide treatment that can be delivered within a 7-
day period. Here we have identified a synergy between the anthelmintic albendazole (ABZ) …

Introduction: Antimicrobial dose optimization for the treatment of sepsis remains challenging
because of dynamic pharmacokinetic alterations and physiological/pathological responses …