A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy
F Riccardi, M Dal Bo, P Macor, G Toffoli - Frontiers in Pharmacology, 2023 - frontiersin.org
Antibody-Drug Conjugates (ADCs) represent an innovative class of potent anti-cancer
compounds that are widely used in the treatment of hematologic malignancies and solid …
compounds that are widely used in the treatment of hematologic malignancies and solid …
Hallmarks of cancer affected by the MIF cytokine family
R Mora Barthelmess, B Stijlemans… - Cancers, 2023 - mdpi.com
Simple Summary The aim of this review is to summarize the available information regarding
the MIF family in cancer, comprising MIF and DDT. Both cytokines are highly expressed in …
the MIF family in cancer, comprising MIF and DDT. Both cytokines are highly expressed in …
Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response
The spatial organization of the tumor microenvironment has a profound impact on biology
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …
CD74 promotes a pro-inflammatory tumor microenvironment by inducing S100A8 and S100A9 secretion in pancreatic cancer
WC Hong, DE Lee, HW Kang, MJ Kim, M Kim… - International Journal of …, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive form of pancreatic cancer with
a poor prognosis and low survival rates. The prognostic and predictive biomarkers of PDAC …
a poor prognosis and low survival rates. The prognostic and predictive biomarkers of PDAC …
Integrated analysis of single-cell RNA-seq and bulk RNA-seq to unravel the molecular mechanisms underlying the immune microenvironment in the development of …
Y Su, X Zhang, Y Liang, J Sun, C Lu… - Biochimica et Biophysica …, 2024 - Elsevier
Intestinal-type gastric cancer (IGC) is the most frequent type of gastric cancer in high-
incidence populations. The early stages of IGC growth successively include nonatrophic …
incidence populations. The early stages of IGC growth successively include nonatrophic …
Tissue inhibitor of metalloproteinases-1 interacts with CD74 to promote AKT signaling, monocyte recruitment responses, and vascular smooth muscle cell proliferation
S Ebert, L Zang, N Ismail, M Otabil, A Fröhlich, V Egea… - Cells, 2023 - mdpi.com
Tissue inhibitor of metalloproteinases-1 (TIMP-1), an important regulator of matrix
metalloproteinases (MMPs), has recently been shown to interact with CD74, a receptor for …
metalloproteinases (MMPs), has recently been shown to interact with CD74, a receptor for …
Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation
J Liu, Y Chen, H Chen, Y Wang, D Li, Q Zhang… - Respiratory …, 2023 - Springer
Background Macrophage migration inhibitory factor (MIF) and GTPase dynamin-related
protein 1 (Drp1)-dependent aberrant mitochondrial fission are closely linked to the …
protein 1 (Drp1)-dependent aberrant mitochondrial fission are closely linked to the …
Single-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 expression
R Wang, L Peng, Y Xiao, Q Zhou, Z Wang, L Tang… - Cancer gene …, 2023 - nature.com
Glioma is the most common primary central nervous system tumor in adults. Aquaporin-4, as
a water channel protein encoded by AQP4 in the brain, is reported to alter its aggregation …
a water channel protein encoded by AQP4 in the brain, is reported to alter its aggregation …
Intratumoral CD103+CD8+ T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma
S Ren, T Lan, F Wu, S Chen, X Jiang… - Cancer …, 2023 - Wiley Online Library
Background Immune cell heterogenicity is known to determine the therapeutic response to
cancer progression. Neoadjuvant chemoimmunotherapy (NACI) has shown clinical benefits …
cancer progression. Neoadjuvant chemoimmunotherapy (NACI) has shown clinical benefits …
ADAM10 and ADAM17, major regulators of chronic kidney disease induced atherosclerosis?
SL Maas, MMPC Donners… - International journal of …, 2023 - mdpi.com
Chronic kidney disease (CKD) is a major health problem, affecting millions of people
worldwide, in particular hypertensive and diabetic patients. CKD patients suffer from …
worldwide, in particular hypertensive and diabetic patients. CKD patients suffer from …