Highlights•Pharmacological treatment of chronic pain and migraine remains unsatisfactory.•
Chronic pain and migraine share some common pathophysiological mechanisms.•Drug …

Traumatic brain injury is a major source of global disability and mortality. Preclinical TBI
models are a crucial component of therapeutic investigation. We report a tunable, monitored …

Epidemiological data suggest that elevated homocysteine is associated with migraine with
aura. However, how homocysteine contributes to migraine is still unclear. Here, we tested …

Oxytocinergic transmission blocks nociception at the peripheral, spinal, and supraspinal
levels through the oxytocin receptor (OTR). Indeed, a neuronal pathway from the …

Inflammation or injuries of the trigeminal nerve are often associated with persistent facial
pain and its sequelae. A number of models have been described to study trigeminal pain in …

Background Recent studies have indicated that P2Y receptors in spinal microglia play a role
in the development of neuropathic and inflammatory pain. However, it remains unclear …

Purpose: Chronic ocular pain is poorly understood and difficult to manage. We developed a
murine model of corneal surface injury (CSI)–induced chronic ocular neuropathic pain. The …

Neuropathic pain refers to pain caused by lesions or diseases of the somatosensory
nervous system that is characteristically different from nociceptive pain. Moreover …

Patients with Alzheimer's disease (AD) present with a variety of symptoms, including core
symptoms as well as behavioral and psychological symptoms. Somatosensory neural …

Neuropathic pain is known to be attributable to the injured nerve, a postoperative problem
induced by surgery. The infraorbital nerve (ION), a branch of the trigeminal nerve, innervates …