Background The global burden of invasive fungal infections (IFIs) has shown an upsurge in
recent years due to the higher load of immunocompromised patients suffering from various …

Cryptococcosis is an infection of global significance, affecting both immunocompromised
and immunocompetent hosts. Traditionally, 2 main species of yeasts caused cryptococcosis …

Background Cryptococcal meningitis is the most common cause of meningitis in adults living
with HIV in sub-Saharan Africa. The estimates of national, regional, and global burden of …

Background Diagnosing invasive or chronic fungal infections is a challenge, particularly in
the immunocompromised host. Microscopy and culture remain the reference standard, but …

The genus Cryptococcus contains two primary species complexes that are significant
opportunistic human fungal pathogens: C. neoformans and C. gattii. In humans …

Background Fungal infections are common causes of death and morbidity in those with
advanced HIV infection. Data on access to diagnostic tests in Africa are scarce. We aimed to …

Next-generation sequencing (NGS) technologies have recently developed beyond the
research realm and started to mature into clinical applications. Here, we review the current …

Central nervous system (CNS) cryptococcosis in non-HIV infected patients affects solid
organ transplant (SOT) recipients, patients with malignancy, rheumatic disorders, other …

Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …

The endemic mycoses blastomycosis, coccidioidomycosis, histoplasmosis,
paracoccidioidomycosis, cryptococcosis, sporotrichosis, talaromycosis, adiaspiromycosis …