Introduction We systematically reviewed extant studies evaluating the efficacy and
tolerability of xanomeline and xanomeline-trospium (KarXT) for treatment of adults with …

Introduction The roles of metabolic signals, including Glucagon-like peptide 1 (GLP-1), have
been implicated in multiple domains outside metabolic regulation. There is a growing …

Baek et al in this issue of the Journal present results from a longitudinal observational study
that aimed to ascertain whether a correlation exists between depressive symptom …

Within the last year, the European Medicines Agency (EMA), Food and Drug Administration
(FDA) and the Medicines and Healthcare Products Regulatory Agency in the United …

Classical examples of disorders associated with body image disturbances are eating
disorders (EDs) such as anorexia nervosa (AN) and bulimia nervosa (BN), as well as body …

Obesity is a disease of epidemic proportions in the United States and contributes to
morbidity and mortality for a large part of the population. In addition, the financial costs of this …

This issue of the Journal is focused on themes relevant to improving clinical outcomes with
current treatments as well as informing new treatments under development. Specific topics …

Abstract In ESCAPE-TRD (NCT04338321), esketamine nasal spray (NS) significantly
increased the probability of remission at Week 8, and of being relapse-free through Week 32 …

The prevalence of depression continues to rise, and it has a high death and disability rate.
Life's Essential 8 (LE8) is an updated measurement of cardiovascular health (CVH), and the …

Psychotropic drugs are pivotal in managing a spectrum of mental health disorders, operating
by selectively modulating the central nervous system (CNS). The CNS serves as the primary …