Sorafenib is the first drug approved to treat advanced hepatocellular carcinoma (HCC) and
continues as the gold-standard therapy against HCC. However, acquired drug resistance …

Tumor necrosis factor-α (TNF-α), an inflammatory cytokine, is produced by monocytes and
macrophages. It is known as a'double-edged sword'because it is responsible for …

Despite the proliferation of medications and therapies for cancer patients, cancer is an
illness that significantly influences the expectancy and quality of life. Globally, there is a …

Simple Summary Liver cancer represents one of the most lethal forms of cancer, with
hepatocellular carcinoma (HCC) accounting for the majority of its incidences and deaths …

Abstract Type 2 Diabetes Mellitus (T2DM) is characterized by hepatic insulin resistance,
which results in increased glucose production and reduced glycogen storage in the liver …

The polypeptide antibiotic Polymyxin B (PMB) can cause acute kidney injury (AKI), we found
that ferroptosis is one of the main mechanisms of renal injury caused by PMB. It was …

Recently, phosphodiesterases (PDEs) have gained great attention due to their implication in
Parkinson's disease (PD) pathogenesis. Noteworthy, the PDE4 enzyme is highly expressed …

Saffron is located in the upper part of the crocus stigma of iridaceae, which has a long
history of medicinal use. Crocin (molecular formula C 44 H 64 O 24) is a natural floral …

Doxorubicin (DXR) is widely used in cancer treatment. However, it has not yet been possible
to prevent the side effects of DXR. The aim of this study was to investigate the …

Abstract Ethnopharmacological relevance Epimedium sagittatum (Sieb. et Zucc.) Maxim. has
been used traditionally in Asia. It can dispel wind and cold, tonify the kidney, and strengthen …