Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …

Regulatory science for generic dry powder inhalers (DPIs) in the United States (US) has
evolved over the last decade. In 2013, the US Food and Drug Administration (FDA) …

Uncovering differences between crystalline and amorphous states in molecular solids would
both promote the understanding of their structure–property relationships, as well as inform …

This work describes the use of fused deposition modelling (FDM) to prepare antiplatelet
thermoplastic polyurethane (TPU)-based tubular grafts. FDM 3D-printing technology is …

In recent years, poorly water-soluble drug candidates in the drug development pipeline have
been a challenging issue for the pharmaceutical industry. Many delivery systems such as …

The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

The physiochemical characteristics of nanoparticles affect their in vitro and in vivo
performance significantly, such as diameter, surface chemistry, and shape. This paper …

Flavonoids have many positive pharmacological properties, such as antioxidant, antitumor,
and anti-inflammatory activities. However, factors such as low water solubility and low …

Poor solubility is a major challenge that can limit the oral bioavailability of many drugs,
including delamanid, a weakly basic nitro-dihydro-imidazooxazole derivative used to treat …

In this Commentary, the authors expand on their earlier studies of the solid-state long-term
isothermal crystallization of amorphous API from the glassy state in amorphous solid …