Anticancer therapeutic potential of benzofuran scaffolds
Benzofuran moiety is the main component of many biologically active natural and synthetic
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
Multi-therapies based on PARP inhibition: potential therapeutic approaches for cancer treatment
J Zhang, Y Gao, Z Zhang, J Zhao, W Jia… - Journal of Medicinal …, 2022 - ACS Publications
The nuclear enzymes called poly (ADP-ribose) polymerases (PARPs) are known to catalyze
the process of PARylation, which plays a vital role in various cellular functions. They have …
the process of PARylation, which plays a vital role in various cellular functions. They have …
Unexpected products using Biginelli reaction: Synthesis, antimicrobial potency, docking simulation, and DFT investigations of some new amidopyridines
The Biginelli reaction of 3-oxo-N-(2-pyridyl) butanamide with thiourea (or urea) and some
aromatic aldehydes afforded new chemical skeletons containing tetrahydropyrimidine …
aromatic aldehydes afforded new chemical skeletons containing tetrahydropyrimidine …
Synthesis of novel mono-and bis-pyrazolylthiazole derivatives as anti-liver cancer agents through EGFR/HER2 target inhibition
Bromoacetyl-4-(2-naphthoyl)-1-phenyl-1H-pyrazole (6) was synthesized from 2-
acetylnaphthalene and was used as a new key building block for constructing the title …
acetylnaphthalene and was used as a new key building block for constructing the title …
Epidermal growth factor receptor dual-target inhibitors as a novel therapy for cancer: A review
C Wang, Y Zhang, T Zhang, J Xu, S Yan, B Liang… - International Journal of …, 2023 - Elsevier
Overexpression of the epidermal growth factor receptor (EGFR) has been linked to several
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …
Synthesis, crystal structure, DFT, Hirshfeld surface analysis, energy frameworks and in-Silico drug-targeting PFKFB3 kinase of novel triazolequinoxalin derivative (TZQ …
Overall, drug design is a dynamic and evolving field, with researchers constantly working to
improve their understanding of molecular interactions, develop new computational methods …
improve their understanding of molecular interactions, develop new computational methods …
Synthesis and Anti-Breast Cancer Potency of Mono- and Bis-(pyrazolyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine) Derivatives as EGFR/CDK-2 Target Inhibitors
The target mono-and bis-(6-pyrazolyltriazolo-thiadiazine) derivatives 4a-c and 6a-d were
synthesized using a straightforward protocol via reaction of 3-bromoacetylpyrazole 2 with 4 …
synthesized using a straightforward protocol via reaction of 3-bromoacetylpyrazole 2 with 4 …
Recent developments in the chemistry of 1H-and 4H-1, 2, 4-triazoles
Abstract 1H-and 4H-1, 2, 4-Triazoles have wide potent biological applications; therefore,
developing new synthetic routes for such interesting scaffolds is of great importance. The …
developing new synthetic routes for such interesting scaffolds is of great importance. The …
[HTML][HTML] Synthetic Methods and Pharmacological Potentials of Triazolothiadiazines: A Review
This review article examines the synthetic pathways for triazolothiadiazine derivatives, such
as triazolo [3, 4-b] thiadiazines, triazolo [5, 1-b] thiadiazines, and triazolo [4, 3-c] …
as triazolo [3, 4-b] thiadiazines, triazolo [5, 1-b] thiadiazines, and triazolo [4, 3-c] …
Synthesis of novel piperazine-based bis (thiazole)(1, 3, 4-thiadiazole) hybrids as anti-cancer agents through caspase-dependent apoptosis
A series of novel piperazine-based bis (thiazoles) 13a–d were synthesized in moderate to
good yields via reaction of the bis (thiosemicarbazones) 7a, b with an assortment of C-acetyl …
good yields via reaction of the bis (thiosemicarbazones) 7a, b with an assortment of C-acetyl …