ABCB1 (MDR1) is one of many ubiquitous adenosine triphosphate (ATP)-binding cassette
(ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3] …

Cancer is one of the leading causes of mortality in the developed countries. The search for
novel drug candidates is a priority goal for cancer therapy. However, the emergence of drug …

Drug processing genes (DPGs), namely uptake transporters, phase-I and phase-II enzymes,
as well as efflux transporters are responsible for the absorption, distribution, metabolism …

Background Resistance of the highly aggressive glioblastoma multiforme (GBM) to drug
therapy is a major clinical problem resulting in a poor patient's prognosis. Beside promoter …

Genetic variants of ABCB1 may affect intestinal absorption of aspirin (ASA). However, it is
unclear whether ABCB1 polymorphisms and DNA methylation are associated with ASA …

Purpose To investigate the influence of ABCB1 polymorphisms on prognostic outcomes in
Chinese patients with de novo intermediate-risk acute myeloid leukemia (AML) and to …

Abstract P‐glycoprotein (P‐gp) is an efflux transporter involved in the bioavailability of many
drugs currently on the market. P‐gp is responsible for several drug–drug interactions …

Abstract Background and Objectives It is well known that the expression and function of ATP-
binding cassette transporter B1 (ABCB1) show high interindividual variability, but the …

ABCB1 gene overexpression has been described as an important mechanism for resistance
to conventional chemotherapy in multiple myelomas. In the refractory multiple myelomas …

Despite their clearly distinct pathophysiologies, HIV and cancer are diseases whose
response to chemotherapy treatment varies substantially amongst patients, in particular for …