Although Parkinson disease (PD) is viewed traditionally as a motor syndrome secondary to
nigrostriatal dopaminergic denervation, recent studies emphasize non-motor features. Non …

It is not yet established whether oxidative stress is a major cause of cell death or simply a
consequence of an unknown pathogenetic factor. Concerning chronic diseases, as …

The organization of projections from the cholinergic neurons of the basal forebrain to
neocortex and associated structures was investigated in the rhesus monkey with the help of …

In the brains of humans and other mammals, there are two principal groups of cholinergic
nuclei aside from those forming the cranial motor nuclei. One group lies in the forebrain and …

As many as two million people in the United Kingdom repeatedly see people, animals, and
objects that have no objective reality. Hallucinations on the border of sleep, dementing …

Background Pathology reports have shown that cholinergic forebrain neuronal losses in
parkinsonian dementia (PDem) are equal to or greater than those in Alzheimer disease …

Dementia in Parkinson's disease has previously been attributed to the presence in the
cerebral cortex of Alzheimer-type neuropathological abnormalities. New evidence suggests …

The nucleus basalis of Meynert, the major source of cholinergic innervation of the cerebral
cortex, was morphometrically investigated in 58 cases of neuropsychiatric disorders and …

To map presynaptic cholinergic terminal densities in normal aging (n= 36), Alzheimer's
disease (AD)(n= 22), and Parkinson's disease (PD)(n= 15), we performed singlephoton …

Demented patients with Parkinson disease share certain neuropathological and
neurochemical features with patients suffering from Alzheimer disease. Recently, loss of …