Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous
drinking, defined by quantity and frequency of consumption, is associated with acute and …

Alcohol use produces wide-ranging and diverse effects on the central nervous system. It
influences intracellular signaling mechanisms, leading to changes in gene expression …

The central nucleus of the amygdala (CEA) is a brain region that integrates external and
internal sensory information and executes innate and adaptive behaviors through distinct …

Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …

The persistence of drug taking despite its adverse consequences plays a central role in the
presentation, diagnosis, and impacts of addiction. Eventual recognition and appraisal of …

The central amygdala (CeA) contains a diverse population of cells, including multiple
subtypes of GABAergic neurons, along with glia and epithelial cells. Specific CeA cell types …

Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

Excessive alcohol consumption remains a global public health crisis, with millions suffering
from alcohol use disorder (AUD, or simply “alcoholism”), leading to significantly reduced life …

The bed nucleus of the stria terminalis (BNST) is a critical mediator of stress responses and
anxiety-like behaviors. Neurons expressing protein kinase C delta (BNSTPKCδ) are an …

Alcohol Use Disorder (AUD) ranks among the most prevalent mental disorders, extracting~
$250 billion/year in the US alone and producing myriad medical and social harms. Also, the …