Hepatocellular carcinoma downstaging for liver transplantation in the era of systemic combined therapy with anti‐VEGF/TKI and immunotherapy

NH Tran, S Muñoz, S Thompson, CL Hallemeier… - Hepatology, 2022 - journals.lww.com
Hepatocellular carcinoma remains a global health challenge affecting close to 1 million
cases yearly. Liver transplantation provides the best long‐term outcomes for those meeting …

Systemic neoadjuvant and adjuvant therapies in the management of hepatocellular carcinoma—a narrative review

S Chamseddine, M LaPelusa, AO Kaseb - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is the most common type of liver cancer,
accounting for approximately 85–90% of all cases of liver cancer worldwide. The five-year …

Hepatectomy after conversion therapy using tyrosine kinase inhibitors plus anti-PD-1 antibody therapy for patients with unresectable hepatocellular carcinoma

XD Zhu, C Huang, YH Shen, B Xu, NL Ge, Y Ji… - Annals of surgical …, 2023 - Springer
Background Combined treatment with tyrosine kinase inhibitors (TKI) plus anti-PD-1
antibodies showed high anti-tumor efficacy and made conversion resection possible for …

Hepatectomy after conversion therapy for initially unresectable HCC: what is the difference?

L Luo, Y He, G Zhu, Y Xiao, S Song, X Ge… - Journal of …, 2022 - Taylor & Francis
Purpose Conversion therapy gives some patients with initially unresectable hepatocellular
carcinoma (HCC) access to surgery. The purpose of this study was to evaluate the safety …

Conversion therapy with an immune checkpoint inhibitor and an antiangiogenic drug for advanced hepatocellular carcinoma: A review

H Tang, Y Cao, Y Jian, X Li, J Li, W Zhang, T Wan… - BioScience …, 2022 - jstage.jst.go.jp
Hepatocellular carcinoma (HCC) has been the fifth most common malignancy worldwide
and is the second most common cause of tumor-related mortality globally. In China, a high …

[HTML][HTML] Lenvatinib plus anti-PD-1 antibodies as conversion therapy for patients with unresectable intermediate-advanced hepatocellular carcinoma: a single-arm …

W Zhang, S Tong, B Hu, T Wan, H Tang… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Over 70% of the patients with hepatocellular carcinoma (HCC) are diagnosed
at an advanced stage and lose the opportunity for radical surgery. Combination therapy of …

Transarterial Chemoembolization Plus Lenvatinib and PD-1 inhibitors for Hepatocellular Carcinoma with main trunk portal vein tumor Thrombus: a Multicenter …

SQ Li, JY Wu, JY Wu, H Xie, JH Li, ZX Zeng… - Journal of …, 2023 - Taylor & Francis
Purpose In recent years, immune checkpoint inhibitors have been used in combination with
tyrosine kinase inhibitors and local therapies, creating a new era in treating hepatocellular …

Preoperative immunotherapy in hepatocellular carcinoma: Current state of the art

A Laschtowitz, C Roderburg, F Tacke… - Journal of …, 2023 - Taylor & Francis
Hepatocellular carcinoma (HCC) is a malignancy that requires multidisciplinary evaluation
to develop individualized and tailored treatment concepts. While liver resection and …

Perioperative safety, oncologic outcome, and risk factors of salvage liver resection for initially unresectable hepatocellular carcinoma converted by transarterial …

KY Lin, ZW Lin, QJ Chen, LP Luo, JX Zhang… - Hepatology …, 2023 - Springer
Background To assess the perioperative safety, oncological outcomes, and determinants
influencing the oncological outcomes of salvage liver resection for initially unresectable …

Real-world practice of conversion surgery for unresectable hepatocellular carcinoma-a single center data of 26 consecutive patients

B Zhang, X Shi, K Cui, Z Li, L Li, Z Liu, C Zhang, P Sun… - BMC cancer, 2023 - Springer
Aim To understand the proportion of uHCC (unresectable hepatocellular carcinoma)
patients who achieve successful conversion resection in a high-volume setting with state of …