Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Background: Frontotemporal dementia (FTD) describes a cluster of neurocognitive
syndromes that present with impairment of executive functioning, changes in behavior, and …

Frontotemporal dementia (FTD) is the second most prevalent form of early-onset dementia,
affecting predominantly frontal and temporal cerebral lobes. Heterozygous mutations in the …

Inflammation is emerging as a critical mechanism underlying neurological disorders of
various etiologies, yet its role in altering brain function as a consequence of neuroinfectious …

Background There are few validated fluid biomarkers in frontotemporal dementia (FTD).
Glial fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological …

Misfolded or mislocalized RNA‐binding proteins (RBP s) and, consequently, altered mRNA
processing, can cause neuronal dysfunction, eventually leading to neurodegeneration. Two …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome associated with
frontotemporal lobar degeneration (FTLD) as a relatively consistent neuropathological …

Behavioral variant frontotemporal dementia (bvFTD) is the second leading cognitive
disorder caused by neurodegeneration in patients under 65 years of age. Characterized by …

Frontotemporal dementias are a clinically, neuroanatomically, and pathologically diverse
group of diseases that collectively constitute an important cause of young-onset dementia …