Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

Research on age-related regenerative failure of skeletal muscle has extensively focused on
the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory …

Pathologic skin scarring presents a vast economic and medical burden. Unfortunately, the
molecular mechanisms underlying scar formation remain to be elucidated. We used a …

Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

During aging, the regenerative capacity of skeletal muscle decreases due to intrinsic
changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we use …

Multiple viral pathogens can pose a significant health risk to individuals. As a recent
example, the β-coronavirus family virion, SARS-CoV-2, has quickly evolved as a pandemic …

Background: The mammalian circadian clock and its associated clock genes are
increasingly been recognized as critical components for a number of physiological and …

Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) signaling is one of
the most critical pathways in developing and adult tissues. In the brain, Wnt signaling …

It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …