Signaling pathways driving ocular malignancies and their targeting by bioactive phytochemicals

CR Croley, J Pumarol, BE Delgadillo, AC Cook… - Pharmacology & …, 2023 - Elsevier
Ocular cancers represent a rare pathology. The American Cancer Society estimates that
3,360 cases of ocular cancer occur annually in the United States. The major types of cancers …

[HTML][HTML] Molecular Mechanisms of Flavonoids against Tumor Gamma-Herpesviruses and Their Correlated Cancers—A Focus on EBV and KSHV Life Cycles and …

STS Hassan, M Šudomová - International Journal of Molecular Sciences, 2022 - mdpi.com
Epstein–Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) are cancer-
causing viruses that belong to human gamma-herpesviruses. They are DNA viruses known …

[HTML][HTML] Exploring the underlying mechanisms of fisetin in the treatment of hepatic insulin resistance via network pharmacology and in vitro validation

T Li, J Ling, X Du, S Zhang, Y Yang, L Zhang - Nutrition & Metabolism, 2023 - Springer
Objective To characterize potential mechanisms of fisetin on hepatic insulin resistance (IR)
using network pharmacology and in vitro validation. Methods Putative targets of fisetin were …

Exploration of potential targets and mechanisms of fisetin in the treatment of non‐small‐cell lung carcinoma via network pharmacology and in vitro validation

J Ling, Y Wang, L Ma, A Chang… - Evidence‐Based …, 2022 - Wiley Online Library
Purpose. The morbidity and fatality rates of non‐small‐cell lung cancer (NSCLC) were high,
although a combination of multiple treatments was used. Fisetin, a small flavonoid …

[HTML][HTML] Fisetin Protects C2C12 Mouse Myoblasts from Oxidative Stress-Induced Cytotoxicity through Regulation of the Nrf2/HO-1 Signaling

C Park, HJ Cha, DH Kim, CY Kwon… - … of Microbiology and …, 2023 - ncbi.nlm.nih.gov
Fisetin is a bioactive flavonol molecule and has been shown to have antioxidant potential,
but its efficacy has not been fully validated. The aim of the present study was to investigate …

Fisetin-loaded grape-derived nanoparticles improve anticancer efficacy in MOLT-4 cells

P Sarvarian, P Samadi, E Gholipour… - Biochemical and …, 2023 - Elsevier
Purpose Fisetin (FIS) is a natural flavonoid with anti-proliferative and anti-apoptotic effects
on different human cancer cell lines and can be considered a therapeutic agent for ALL …

[HTML][HTML] Autophagy as a therapeutic target of natural products enhancing embryo implantation

H Park, M Cho, Y Do, JK Park, SJ Bae, J Joo, KT Ha - Pharmaceuticals, 2021 - mdpi.com
Infertility is an emerging health issue worldwide, and female infertility is intimately
associated with embryo implantation failure. Embryo implantation is an essential process …

Fisetin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF

M Lai, C Lan, J Zhong, L Wu, C Lin - Journal of Ophthalmology, 2023 - Wiley Online Library
Diabetic retinopathy (DR) is one of the more serious complications of diabetes. However, the
mechanisms involved in DR are complex and still need to be investigated. The beneficial …

Genistein: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

JS Katanić Stanković, N Mihailović… - Handbook of Dietary …, 2023 - Springer
Genistein is considered one of the most active natural flavonoids. It has an isoflavonoid
structure and expresses a variety of health benefits. This compound is considered one of the …

Fisetin reduces the resistance of MOLT-4 and K562 cells to TRAIL-induced apoptosis through upregulation of TRAIL receptors

L Liu, SA Hussain, X Hu - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that is
capable of apoptosis induction selectively in tumor cells. Although TRAIL has been …