Excessive activity of the Fas system in the liver is an essential event and contributor to
fulminant hepatic failure, whose prognosis is extremely poor with high mortality due to lack …

Mesenchymal-epithelial tissue interactions are important for development of various organs,
and in many cases, soluble signaling molecules may be involved in this interaction …

Fibrosis affects multiple organs and is associated with hyperproliferation, cell
transdifferentiation, matrix modification and contraction. It is therefore essential to discover …

Invasion of various carcinoma cells follows their interaction with stromal cells. Hepatocyte
growth factor (HGF), four-kringle-containing growth factor, is a mesenchymal or stromal …

For cancer metastasis, tumor cells present in the circulation must first adhere to the
endothelium. Integrins lymphocyte function-associated antigen (LFA) 1 and very late antigen …

Hepatocyte growth factor (HGF) is a mitogen for hepatocytes, but it is not clear whether HGF
stimulates or inhibits hepatocarcinogenesis. We previously reported that HGF transgenic …

Met is the transmembrane tyrosine kinase cell surface receptor for hepatocyte growth factor
(HGF) and is structurally related to the insulin receptor (INSR) tyrosine kinase. Here we …

Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix
degradation pathways. Background Hepatocyte growth factor (HGF) has been shown to …

Background—In patients with acute coronary syndromes, compensatory processes are
initiated, including angiogenesis and endothelial regeneration of ruptured or eroded …

Intracellular pathogens mobilize host signaling pathways of their host cell to promote their
own survival. Evidence is emerging that signal transduction elements are activated in a …