The ATP analog K252a is a potent inhibitor for receptor tyrosine kinases of the Trk family.
Here we show that nanomolar concentrations of K252a prevent HGF-mediated scattering in …

Hepatocyte growth factor (HGF) signaling via the MET receptor is essential for embryonic
development and tissue repair. On the other hand, deregulated MET signaling promotes …

The exquisite ability of the liver to regenerate is finite. Identification of mechanisms that limit
regeneration after massive injury holds the key to expanding the limits of liver …

Recent studies have revealed that bone marrow cells can develop into hepatocytes by in
vivo transplantation under certain circumstances. However, little is known about the …

The activation of hepatocyte growth factor (HGF)/scatter factor (SF) in an extracellular milieu
is a critical limiting step in HGF/SF-induced signaling that is believed to have important roles …

Mechanisms leading to the development of virulent prostate cancer are not confined to the
cancer epithelial cell, but also involve the tumor microenvironment. Multiple signaling …

Hepatocyte growth factor/scatter factor (HGF/SF) is a heparin-binding polypeptide that
stimulates cell proliferation, motility, and morphogenesis by activation of its receptor, the c …

The receptor for hepatocyte growth factor (HGF) is a transmembrane tyrosine kinase that is
encoded by the proto-oncogene c-met. Recently, c-MET was detected in Reed-Sternberg …

Hepatocyte growth factor (HGF) identical to scatter factor (SF) is a glycoprotein involved in
the development of a number of cellular phenotypes, including proliferation, mitogenesis …

Acute graft-versus-host disease (GVHD) is a major complication of bone marrow
transplantation (BMT) and is characterized by hematopoietic dysfunction …