EZH2-targeted therapies in cancer: hype or a reality
ML Eich, M Athar, JE Ferguson III, S Varambally - Cancer research, 2020 - AACR
Next-generation genomic sequencing has identified multiple novel molecular alterations in
cancer. Since the identification of DNA methylation and histone modification, it has become …
cancer. Since the identification of DNA methylation and histone modification, it has become …
[HTML][HTML] Cell of origin and genetic alterations in the pathogenesis of multiple myeloma
BG Barwick, VA Gupta, PM Vertino… - Frontiers in …, 2019 - frontiersin.org
B cell activation and differentiation yields plasma cells with high affinity antibodies to a given
antigen in a time-frame that allows for host protection. Although the end product is most …
antigen in a time-frame that allows for host protection. Although the end product is most …
Lysine demethylase KDM6A in differentiation, development, and cancer
ABSTRACT Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6
family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B …
family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B …
[HTML][HTML] The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer …
Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer …
passenger mutations, which occur as byproducts of cancer development. The cancer …
[HTML][HTML] TP63-mediated enhancer reprogramming drives the squamous subtype of pancreatic ductal adenocarcinoma
The aberrant expression of squamous lineage markers in pancreatic ductal
adenocarcinoma (PDA) has been correlated with poor clinical outcomes. However, the …
adenocarcinoma (PDA) has been correlated with poor clinical outcomes. However, the …
[HTML][HTML] Recent advances in diabetic kidney diseases: from kidney injury to kidney fibrosis
PH Hung, YC Hsu, TH Chen, CL Lin - International Journal of Molecular …, 2021 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-
stage renal disease. The natural history of DKD includes glomerular hyperfiltration …
stage renal disease. The natural history of DKD includes glomerular hyperfiltration …
[HTML][HTML] Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
To separate causal effects of histone acetylation on chromatin accessibility and
transcriptional output, we used integrated epigenomic and transcriptomic analyses following …
transcriptional output, we used integrated epigenomic and transcriptomic analyses following …
[HTML][HTML] Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma
Interplay between chromatin-associated complexes and modifications critically contribute to
the partitioning of epigenome into stable and functionally distinct domains. Yet there is a lack …
the partitioning of epigenome into stable and functionally distinct domains. Yet there is a lack …
[HTML][HTML] UTX mutations in human cancer
L Wang, A Shilatifard - Cancer cell, 2019 - cell.com
Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX, encoded by
KDM6A) is a histone demethylase that targets di-and tri-methylated histone H3 lysine 27 …
KDM6A) is a histone demethylase that targets di-and tri-methylated histone H3 lysine 27 …
Histone lysine demethylases and their functions in cancer
J Sterling, SV Menezes, RH Abbassi… - International Journal of …, 2021 - Wiley Online Library
Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on
lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene …
lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene …