Osteoporosis is becoming a major concern in the field of public health. The process of bone
loss is insidious and does not directly induce obvious symptoms. Complications indicate an …

The formation of osteoclasts and their hyperactive bone resorption are related to the
aggregation of intracellular reactive oxygen species (ROS). Flavonoids, derived from plant …

Activating Nrf2 by small molecules is a promising strategy to treat postmenopausal
osteoporosis. However, there is currently no Nrf2 activator approved for treating chronic …

Declining estrogen production in postmenopausal females causes osteoporosis in which the
resorption of bone exceeds the increase in bone formation. Although clinical drugs are …

Background and purpose Inflammatory disorders have been found to induce bone loss
through sustained and persistent activation of osteoclast differentiation, leading to …

Sestrins are stress-responsive proteins with antioxidant properties. They participate in
cellular redox balance and protect against oxidative damage. This study investigated the …

Osteoporosis is a degenerative disease affecting millions of elderly people globally and
increases the risk of bone fractures due to the reduced bone density. Drugs are normally …

Echinatin is an active ingredient in licorice, a traditional Chinese medicine used in the
treatment of inflammatory disorders. However, the protective effect and underlying …

The type and composition of food strongly affect the variation and enrichment of the gut
microbiota. The gut–microbiota–spleen axis has been developed, incorporating the spleen's …

Antioxidants represent a powerful tool for many human diseases and, in particular,
molecular hydrogen has unique characteristics that make it a very promising therapeutic …