Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …
and mortality. There have been significant management advances over the past 2 decades …
Cardiac alternans: from bedside to bench and back
Cardiac alternans arises from dynamical instabilities in the electrical and calcium cycling
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …
Atrial myocyte NLRP3/CaMKII nexus forms a substrate for postoperative atrial fibrillation
Rationale: Postoperative atrial fibrillation (POAF) is a common and troublesome
complication of cardiac surgery. POAF is generally believed to occur when postoperative …
complication of cardiac surgery. POAF is generally believed to occur when postoperative …
[HTML][HTML] Interleukin-6-mediated-Ca2+ handling abnormalities contributes to atrial fibrillation in sterile pericarditis rats
J Liao, S Zhang, S Yang, Y Lu, K Lu, Y Wu… - Frontiers in …, 2021 - frontiersin.org
Pre-existing Ca 2+ handling abnormalities constitute the arrhythmogenic substrate in
patients developing postoperative atrial fibrillation (POAF), a common complication after …
patients developing postoperative atrial fibrillation (POAF), a common complication after …
Advances in basic and translational research in atrial fibrillation
D Hu, H Barajas-Martinez… - … of the Royal …, 2023 - royalsocietypublishing.org
Atrial fibrillation (AF) is a very common cardiac arrhythmia with an estimated prevalence of
33.5 million patients globally. It is associated with an increased risk of death, stroke and …
33.5 million patients globally. It is associated with an increased risk of death, stroke and …
[HTML][HTML] Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium …
Background Malignant ventricular arrhythmia (VA) is a major contributor to sudden cardiac
death (SCD) in patients with pulmonary arterial hypertension (PAH)-induced right heart …
death (SCD) in patients with pulmonary arterial hypertension (PAH)-induced right heart …
RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease
Diastolic Ca 2+ leak due to cardiac ryanodine receptor (RyR2) hyperactivity has been widely
documented in chronic ischemic heart disease (CIHD) and may contribute to ventricular …
documented in chronic ischemic heart disease (CIHD) and may contribute to ventricular …
[HTML][HTML] Revisiting antiarrhythmic drug therapy for atrial fibrillation: reviewing lessons learned and redefining therapeutic paradigms
M Geng, A Lin, TP Nguyen - Frontiers in Pharmacology, 2020 - frontiersin.org
Since the clinical use of digitalis as the first pharmacological therapy for atrial fibrillation (AF)
235 years ago in 1785, antiarrhythmic drug therapy has advanced considerably and …
235 years ago in 1785, antiarrhythmic drug therapy has advanced considerably and …
Atrial fibrillation in horses part 1: Pathophysiology
A Decloedt, G Van Steenkiste, L Vera, R Buhl… - The Veterinary …, 2020 - Elsevier
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia in horses, with a
reported prevalence up to 2.5%. The pathophysiology has mainly been investigated in …
reported prevalence up to 2.5%. The pathophysiology has mainly been investigated in …
[HTML][HTML] Molecular insights in atrial fibrillation pathogenesis and therapeutics: a narrative review
KA Papathanasiou, SG Giotaki, DA Vrachatis, G Siasos… - Diagnostics, 2021 - mdpi.com
The prevalence of atrial fibrillation (AF) is bound to increase globally in the following years,
affecting the quality of life of millions of people, increasing mortality and morbidity, and …
affecting the quality of life of millions of people, increasing mortality and morbidity, and …