89Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art 89Zr Radiochemistry

S Heskamp, R Raavé, O Boerman… - Bioconjugate …, 2017 - ACS Publications
Immuno-positron emission tomography (immunoPET) with 89Zr-labeled antibodies has
shown great potential in cancer imaging. It can provide important information about the …

[HTML][HTML] 89Zr-PET imaging in humans: a systematic review

MS De Feo, M Pontico, V Frantellizzi, F Corica… - Clinical and …, 2022 - Springer
Purpose The remarkable amount of preclinical data achieved on 89 Zr-PET imaging led to a
significant clinical translation, concerning mainly immuno-PET applications. The aim of this …

Alternative Chelator for 89Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO)

MA Deri, S Ponnala, BM Zeglis, G Pohl… - Journal of medicinal …, 2014 - ACS Publications
Zirconium-89 is an effective radionuclide for antibody-based positron emission tomography
(PET) imaging because its physical half-life (78.41 h) matches the biological half-life of IgG …

A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

SE Rudd, P Roselt, C Cullinane, RJ Hicks… - Chemical …, 2016 - pubs.rsc.org
A squaramide ester derivative of desferrioxamine B (H3DFO) that is compatible with
aqueous solvents and does not induce antibody aggregation is used to attach the …

Equilibrium thermodynamics of macropa complexes with selected metal isotopes of radiopharmaceutical interest

MK Blei, L Waurick, F Reissig, K Kopka… - Inorganic …, 2023 - ACS Publications
To pursue the design of in vivo stable chelating systems for radiometals, a concise and
straightforward method toolbox was developed combining NMR, isothermal titration …

Octadentate Picolinic Acid‐Based Bispidine Ligand for Radiometal Ions

P Comba, U Jermilova, C Orvig… - … A European Journal, 2017 - Wiley Online Library
The synthesis of the octadentate bispidine ligand bearing two picolinic acid pendant arms
(H2bispa2), and its coordination chemistry with radionuclides relevant for nuclear medicine …

[HTML][HTML] Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with 152 Tb-DOTATOC

RP Baum, A Singh, M Benešová, C Vermeulen… - Dalton …, 2017 - pubs.rsc.org
The existence of theragnostic pairs of radionuclides allows the preparation of
radiopharmaceuticals for diagnostic and therapeutic purposes. Radiolanthanides, such as …

Exploiting Copper Redox for 19F Magnetic Resonance-Based Detection of Cellular Hypoxia

D Xie, TL King, A Banerjee, V Kohli… - Journal of the American …, 2016 - ACS Publications
We report a pair of fluorinated, redox-active copper complexes for potential use as 19F MRI
contrast agents for detecting cellular hypoxia. Trifluorinated Cu (II) ATSM-F3 displays the …

Chelators and metal complex stability for radiopharmaceutical applications

NC Okoye, JE Baumeister, F Najafi Khosroshahi… - Radiochimica …, 2019 - degruyter.com
Diagnostic and therapeutic nuclear medicine relies heavily on radiometal nuclides. The
most widely used and well-known radionuclide is technetium-99m (99mTc), which has …

[HTML][HTML] Targeted α-therapy of prostate cancer using radiolabeled PSMA inhibitors: a game changer in nuclear medicine

R Chakravarty, CM Siamof, A Dash… - American journal of …, 2018 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is one of the most common malignancies in men and is a major
contributor to cancer related deaths worldwide. Metastatic spread and disease progression …