Cyclic Analogs of Desferrioxamine E Siderophore for 68Ga Nuclear Imaging: Coordination Chemistry and Biological Activity in Staphylococcus aureus

A Mular, A Shanzer, H Kozłowski, I Hubmann… - Inorganic …, 2021 - ACS Publications
As multidrug-resistant bacteria are an emerging problem and threat to humanity, novel
strategies for treatment and diagnostics are actively sought. We aim to utilize siderophores …

A brief overview of metal complexes as nuclear imaging agents

DS MacPherson, K Fung, BE Cook… - Dalton …, 2019 - pubs.rsc.org
Metallic radionuclides have been instrumental in the field of nuclear imaging for over half a
century. While recent years have played witness to a dramatic rise in the use of radiometals …

Radiometals: towards a new success story in nuclear imaging?

D Brasse, A Nonat - Dalton Transactions, 2015 - pubs.rsc.org
Several limitations of 18F and other non-metallic isotopes have been emphasized by the
development of macromolecular biotargeting agents for cancer, including peptides …

Inverse electron demand Diels–Alder click chemistry for pretargeted PET imaging and radioimmunotherapy

SM Sarrett, O Keinänen, EJ Dayts, G Dewaele-Le Roi… - Nature protocols, 2021 - nature.com
Radiolabeled antibodies have shown promise as tools for both the nuclear imaging and
endoradiotherapy of cancer, but the protracted circulation time of radioimmunoconjugates …

Theranostic targeting of CUB domain containing protein 1 (CDCP1) in pancreatic cancer

A Moroz, YH Wang, JM Sharib, J Wei, N Zhao… - Clinical Cancer …, 2020 - AACR
Purpose: The recent emergence of radioligand therapies for cancer treatment has increased
enthusiasm for developing new theranostic strategies coupling both imaging and cytotoxicity …

18F‐Labeled Silicon‐Based Fluoride Acceptors: Potential Opportunities for Novel Positron Emitting Radiopharmaceuticals

V Bernard-Gauthier, C Wängler… - BioMed research …, 2014 - Wiley Online Library
Background. Over the recent years, radiopharmaceutical chemistry has experienced a wide
variety of innovative pushes towards finding both novel and unconventional radiochemical …

[HTML][HTML] The solution thermodynamic stability of desferrioxamine B (DFO) with Zr (IV)

Y Toporivska, E Gumienna-Kontecka - Journal of Inorganic Biochemistry, 2019 - Elsevier
Abstract Desferrioxamine B (DFO,[H 4 L]+, ligand) is currently the preferred chelator for 89 Zr
(IV), however the biological studies suggest that it releases the metal ion in vivo. Herein, we …

What a Difference a Carbon Makes: H4octapa vs H4C3octapa, Ligands for In-111 and Lu-177 Radiochemistry

EW Price, BM Zeglis, JF Cawthray, JS Lewis… - Inorganic …, 2014 - ACS Publications
The acyclic ligands H4C3octapa and p-SCN-Bn-H4C3octapa were synthesized for the first
time, using nosyl protection chemistry. These new ligands were compared to the previously …

Scandium-44: Diagnostic Feasibility in Tumor-Related Angiogenesis

G Trencsényi, Z Képes - International Journal of Molecular Sciences, 2023 - mdpi.com
Angiogenesis-related cell-surface molecules, including integrins, aminopeptidase N,
vascular endothelial growth factor, and gastrin-releasing peptide receptor (GRPR), play a …

Evaluation of hypoxia with copper-labeled diacetyl-bis (N-methylthiosemicarbazone)

SE Lapi, JS Lewis, F Dehdashti - Seminars in nuclear medicine, 2015 - Elsevier
Imaging of hypoxia is important in many diseases states in oncology, cardiology, and
neurology. The radiopharmaceutical, copper-labeled diacetyl-bis (N …