Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a
complex senescence-associated secretory phenotype (SASP). The senescence arrest …

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a
non-uniform phenotype and diverse functional activities. Both tumor-associated …

During the progression of type 1 diabetes (T1D), β cells are exposed to significant stress
and, therefore, require adaptive responses to survive. The adaptive mechanisms that can …

Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …

Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …

Senescence is a cellular program that prevents the replication of old, damaged, or
cancerous cells. Senescent cells become growth arrested and undergo changes in their …

A neoplastic tumor consists of cancer cells that interact with each other and non-cancerous
cells that support the development of the cancer. One such cell are tumor-associated …

NF-κB is generally recognized as an important regulator of ageing, through its roles in
cellular senescence and inflammatory pathways. Activated in virtually all cell-cell …

Background The tumor microenvironment (TME) plays a pivotal role in cancer progression in
papillary thyroid carcinoma (PTC), yet the composition and the phenotype of cells within the …

Dendritic cells (DCs), a class of professional antigen-presenting cells, are considered key
factors in the initiation and maintenance of anti-tumor immunity due to their powerful ability …