[HTML][HTML] Duchenne muscular dystrophy: Disease mechanism and therapeutic strategies

A Bez Batti Angulski, N Hosny, H Cohen… - Frontiers in …, 2023 - frontiersin.org
Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

[HTML][HTML] CRISPR technologies for the treatment of Duchenne muscular dystrophy

E Choi, T Koo - Molecular therapy, 2021 - cell.com
The emerging clustered regularly interspaced short palindromic repeats (CRISPR)-mediated
genome editing technologies have progressed remarkably in recent years, opening up the …

Advances in CRISPR/Cas9 genome editing for the treatment of muscular dystrophies

S Fatehi, RM Marks, MJ Rok, L Perillat… - Human Gene …, 2023 - liebertpub.com
Muscular dystrophies (MDs) comprise a diverse group of inherited disorders characterized
by progressive muscle loss and weakness. Given the genetic etiology underlying MDs …

[HTML][HTML] CRISPR-based therapeutic gene editing for Duchenne muscular dystrophy: advances, challenges and perspectives

G Chen, T Wei, H Yang, G Li, H Li - Cells, 2022 - mdpi.com
Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease arising from loss-
of-function mutations in the dystrophin gene and characterized by progressive muscle …

[HTML][HTML] Targeting Nrf2 for the treatment of Duchenne muscular dystrophy

S Kourakis, CA Timpani, JB de Haan, N Gueven… - Redox biology, 2021 - Elsevier
Imbalances in redox homeostasis can result in oxidative stress, which is implicated in
various pathological conditions including the fatal neuromuscular disease Duchenne …

Role of CRISPR/Cas9 in the treatment of Duchenne muscular dystrophy and its delivery strategies

P Agrawal, V Harish, S Mohd, SK Singh, D Tewari… - Life Sciences, 2023 - Elsevier
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder brought on by mutations
in the DMD gene, which prevent muscle cells from expressing the dystrophin protein …

[PDF][PDF] RETRACTED: Optimizing sgRNA to Improve CRISPR/Cas9 Knockout Efficiency: Special Focus on Human and Animal Cell

S Shojaei Baghini, ZR Gardanova, AO Zekiy… - … in Bioengineering and …, 2021 - frontiersin.org
During recent years, clustered regularly interspaced short palindromic repeat
(CRISPR)/CRISPR-associated protein 9 (Cas9) technologies have been noticed as a rapidly …

[HTML][HTML] Application of CRISPR/Cas9 system in establishing large animal models

Y Lin, J Li, C Li, Z Tu, S Li, XJ Li, S Yan - Frontiers in Cell and …, 2022 - frontiersin.org
The foundation for investigating the mechanisms of human diseases is the establishment of
animal models, which are also widely used in agricultural industry, pharmaceutical …

Developments in reading frame restoring therapy approaches for Duchenne muscular dystrophy

AFE Schneider, A Aartsma-Rus - Expert opinion on biological …, 2021 - Taylor & Francis
Introduction Exon skipping compounds restoring the dystrophin transcript reading frame
have received regulatory approval for Duchenne muscular dystrophy (DMD). Recently, focus …

[PDF][PDF] Modern sustainable techniques for enhancing crop production

A Singh, V Rajput, R Mehrotra, N Pal… - Sustain Soil Fertil …, 2021 - researchgate.net
Due to increasing population, the availability of arable land is declining every year and
environmental factors like global warming, flood, drought, soil toxicity (due to increased use …