Modulating ROS to overcome multidrug resistance in cancer

Q Cui, JQ Wang, YG Assaraf, L Ren, P Gupta… - Drug Resistance …, 2018 - Elsevier
The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

A review on free radicals and antioxidants

H Alkadi - Infectious Disorders-Drug Targets (Formerly Current …, 2020 - ingentaconnect.com
Free radicals are generated in our body by several systems. A balance among free radicals
and antioxidants is an important matter for appropriate physiological function. If free radicals …

Correlation between oxidative stress, nutrition, and cancer initiation

SK Saha, SB Lee, J Won, HY Choi, K Kim… - International journal of …, 2017 - mdpi.com
Inadequate or excessive nutrient consumption leads to oxidative stress, which may disrupt
oxidative homeostasis, activate a cascade of molecular pathways, and alter the metabolic …

Oxidative stress, prooxidants, and antioxidants: the interplay

A Rahal, A Kumar, V Singh, B Yadav… - BioMed research …, 2014 - Wiley Online Library
Oxidative stress is a normal phenomenon in the body. Under normal conditions, the
physiologically important intracellular levels of reactive oxygen species (ROS) are …

RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

S Rezatabar, A Karimian, V Rameshknia… - Journal of cellular …, 2019 - Wiley Online Library
Mitogen‐activated protein kinase (MAPK) signaling pathways organize a great constitution
network that regulates several physiological processes, like cell growth, differentiation, and …

ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

NT Moldogazieva, IM Mokhosoev… - Free radical …, 2018 - Taylor & Francis
Over the last decade, a dual character of cell response to oxidative stress, eustress versus
distress, has become increasingly recognized. A growing body of evidence indicates that …

Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells

DP Bai, XF Zhang, GL Zhang, YF Huang… - International journal …, 2017 - Taylor & Francis
Background Zinc oxide nanoparticles (ZnO NPs) are frequently used in industrial products
such as paint, surface coating, and cosmetics, and recently, they have been explored in …

The roles of ROS in cancer heterogeneity and therapy

PL de Sá Junior, DAD Câmara… - Oxidative medicine …, 2017 - Wiley Online Library
Cancer comprises a group of heterogeneous diseases encompassing high rates of
morbidity and mortality. Heterogeneity, which is a hallmark of cancer, is one of the main …

Redox regulation and its emerging roles in cancer treatment

H Zhang, Z Mao, Y Kang, W Zhang, L Mei… - Coordination Chemistry …, 2023 - Elsevier
Intracellular reduction–oxidation (redox) homeostasis, mediated mainly by reactive oxygen
species (ROS), plays a significant role in physiological function maintenance and regulation …

Mitochondria targeted protein-ruthenium photosensitizer for efficient photodynamic applications

S Chakrabortty, BK Agrawalla, A Stumper… - Journal of the …, 2017 - ACS Publications
Organelle-targeted photosensitization represents a promising approach in photodynamic
therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we …