Sensory neurons with cell bodies situated in dorsal root ganglia convey information from
external or internal sites of the body such as actual or potential harm, temperature or muscle …

Microwave-assisted extraction (MAE) is an emerging technology to obtain polysaccharides
with an extensive spectrum of biological characteristics. In this study, the hypoglycemic …

Membrane ion channels are the fundamental electrical components in the nervous system.
Recent developments in X-ray crystallography and cryo-EM microscopy have revealed what …

Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …

The gem-dimethyl moiety is a structural feature frequently found in many natural products of
clinical interest, including, but not limited to, taxanes, epothilones, statins, retinoids, di …

Background Pain management is a critical aspect of healthcare, aimed at alleviating
discomfort and improving the quality of life for individuals experiencing acute or chronic …

Background and objectives Chronic widespread musculoskeletal pain (CWP) is a symptom
of fibromyalgia and a complex trait with poorly understood pathogenesis. CWP is heritable …

Remifentanil-induced hyperalgesia (RIH) is a severe but common postoperative clinical
problem with elusive underlying neural mechanisms. Here, we discovered that …

Mirogabalin besylate (hereafter mirogabalin)[Tarlige®] is an orally administered
gabapentinoid developed by Daiichi Sankyo for the treatment of peripheral neuropathic pain …

Chronic pain is a major therapeutic problem as the current treatment options are
unsatisfactory with low efficacy and deleterious side effects. Voltage-gated Ca2+ channels …