5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies
by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those …

All of the serotonin-producing neurons of the mammalian brain are located in 10 nuclei in
the mid-and hindbrain regions. The cells of the rostal nuclei project to almost every area of …

Background & Aims: Chemotherapy with an anticancer agent generally causes
gastrointestinal tract disorders such as vomiting and anorexia, but the mechanism remains …

An essential element of the signalling cascade leading to synaptic plasticity is the
intracellular second messenger molecule guanosine 3′, 5′-cyclic monophosphate …

Classical psychedelics are psychoactive substances, which, besides their
psychopharmacological activity, have also been shown to exert significant modulatory …

Extracts of the rhizome of black cohosh [Actaea racemosa L., formerly called Cimicifuga
racemosa (L.) Nutt.] were evaluated for potential mechanisms of action in the alleviation of …

Insomnia is the most frequently encountered sleep complaint worldwide. While many
prescription drugs are used to treat insomnia, extracts of valerian (Valeriana officinalis L …

The serotonin neural system originates from ten nuclei in the mid-and hindbrain regions.
The cells of the rostral nuclei project to almost every area of the forebrain, including the …

Although certain antiparkinson agents interact with serotonin (5-HT) receptors, little
information is available concerning functional actions. Herein, we characterized efficacies of …