Genetic material is constantly subjected to genotoxic insults and is critically dependent on
DNA repair. Genome maintenance mechanisms differ in somatic and germ cells as the soma …

Two related post‐translational modifications, the covalent linkage of Ubiquitin and the Small
Ubiquitin‐related MOdifier (SUMO) to lysine residues, play key roles in the regulation of both …

Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and
require repair by multiple pathways. Whether transcription blockage contributes to the …

DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or
chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based …

Endogenous and exogenous agents generate DNA-protein crosslinks (DPCs), whose
replication-dependent degradation by the SPRTN protease suppresses aging and liver …

DNA-protein crosslinks (DPCs) are pervasive DNA lesions that are induced by reactive
metabolites and various chemotherapeutic agents. Here, we develop a technique for the …

The conserved protein HMCES crosslinks to abasic (AP) sites in ssDNA to prevent strand
scission and the formation of toxic dsDNA breaks during replication. Here, we report a non …

DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …

Reactive aldehydes are abundant endogenous metabolites that challenge homeostasis by
crosslinking cellular macromolecules. Aldehyde-induced DNA damage requires repair to …

Reactive aldehydes are produced by normal cellular metabolism or after alcohol
consumption, and they accumulate in human tissues if aldehyde clearance mechanisms are …