Airway mucus obstruction is a hallmark of many chronic lung diseases including rare genetic
disorders such as cystic fibrosis (CF) and primary ciliary dyskinesia, as well as common lung …

In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection,
inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary …

Inverse Compton scattering provides means to generate low-divergence partially coherent
quasi-monochromatic, ie synchrotron-like, X-ray radiation on a laboratory scale. This …

Background Mucin disulfide cross-links mediate pathologic mucus formation in muco-
obstructive lung diseases. MUC-031, a novel thiol-modified carbohydrate compound …

We present a three-dimensional (3D) approach for virtual histology and histopathology
based on multi-scale phase contrast x-ray tomography, and use this to investigate the …

Objectives. As the central organ of the respiratory system, the human lung is responsible for
supplying oxygen to the blood, which reaches the erythrocytes by diffusion through the …

Cystic fibrosis (CF) is a progressive, chronic and debilitating genetic disease caused by
mutations in the CF Transmembrane-Conductance Regulator (CFTR) gene. Unrelenting …

Background Hyperpolarized noble gas MRI helps measure lung ventilation, but clinical
translation remains limited. Free-breathing proton MRI may help quantify lung function using …

We demonstrate the applicability of propagation-based X-ray phase-contrast imaging at a
laser-assisted compact light source with known phantoms and the lungs and airways of a …

Recent developments in the prediction of local aerosol deposition in human lungs are driven
by the fast development of computational simulations. Although such simulations provide …