In the past decade, significant progress has been made in complex disease research across
multiple omics layers from genome, transcriptome and proteome to metabolome. There is an …

The ambition of precision medicine is to design and optimize the pathway for diagnosis,
therapeutic intervention, and prognosis by using large multidimensional biological datasets …

Background As computational power improves, the application of more advanced machine
learning techniques to the analysis of large genome-wide association (GWA) datasets …

Artificial intelligence is one of the most exciting methodological shifts in our era. It holds the
potential to transform healthcare as we know it, to a system where humans and machines …

Artificial intelligence (AI) digital health systems have drawn much attention over the last
decade. However, their implementation into medical practice occurs at a much slower pace …

Current nutritional and genetic epidemiological methods yield 'risk factors' on the basis of
population studies. Risk factors, however, are statistical estimates of the percentage …

In the last decade, it has been demonstrated that long non-coding RNAs (lncRNAs) are
involved in cancer development. The great majority of studies on lncRNAs report alterations …

Pharmacogenomics is emerging as a popular type of study for human genetics in recent
years. This is primarily due to the many success stories and high potential for translation to …

The detection of genotypes that predict common, complex disease is a challenge for human
geneticists. The phenomenon of epistasis, or gene‐gene interactions, is particularly …

This nested case-control study examined relationships between MDR1, CYP2B6, and
CYP3A4 variants and hepatotoxicity during antiretroviral therapy with either efavirenz-or …