Microbiome diversity protects against pathogens by nutrient blocking

F Spragge, E Bakkeren, MT Jahn, E BN Araujo… - Science, 2023 - science.org
The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We …

[HTML][HTML] Regulation of biofilm formation in Klebsiella pneumoniae

Y Li, M Ni - Frontiers in Microbiology, 2023 - frontiersin.org
Klebsiella pneumoniae is an important Gram-negative opportunistic pathogen that is
responsible for a variety of nosocomial and community-acquired infections. Klebsiella …

[HTML][HTML] Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization

V Horrocks, OG King, AYG Yip, IM Marques… - …, 2023 - microbiologyresearch.org
The human gut microbiota can restrict the growth of pathogens to prevent them from
colonizing the intestine ('colonization resistance'). However, antibiotic treatment can kill …

Urine-mediated suppression of Klebsiella pneumoniae mucoidy is counteracted by spontaneous Wzc variants altering capsule chain length

S Khadka, BE Ring, RS Walker, LR Krzeminski… - Msphere, 2023 - Am Soc Microbiol
Klebsiella pneumoniae is a hospital-associated pathogen primarily causing urinary tract
infections (UTIs), pneumonia, and septicemia. Two challenging lineages include the …

[HTML][HTML] Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae

AL Hecht, LC Harling, ES Friedman… - The Journal of …, 2024 - Am Soc Clin Investig
Bacterial translocation from the gut microbiota is a source of sepsis in susceptible patients.
Previous work suggests that overgrowth of gut pathobionts, including Klebsiella …

Recent advances in a functional deoxy hexose l-fucose: Occurrence, physiological effects, and preparation

J Meng, Y Zhu, N Wang, W Zhang, W Mu - Trends in Food Science & …, 2023 - Elsevier
Background l-Fucose is a functional deoxyhexose prevalent in various organisms.
Particularly, it is the general backbone unit of the polysaccharides of many edible brown …

Characterizing the pathogenic potential of Crohn's disease-associated adherent-invasive Escherichia coli

MT Zangara, L Darwish, BK Coombes - EcoSal Plus, 2023 - Am Soc Microbiol
The microbiome of Crohn's disease (CD) patients is composed of a microbial community that
is considered dysbiotic and proinflammatory in nature. The overrepresentation of …

Metaproteomic assessment of gut microbial and host functional perturbations in Helicobacter pylori-infected patients subjected to an antimicrobial protocol

M Abbondio, A Tanca, L De Diego, R Sau, S Bibbò… - Gut …, 2023 - Taylor & Francis
The impact of therapeutic interventions on the human gut microbiota (GM) is a clinical issue
of paramount interest given the strong interconnection between microbial dynamics and …

Two-Component response regulator ompr regulates mucoviscosity through energy metabolism in Klebsiella pneumoniae

L Wang, X Huang, Q Jin, J Tang, H Zhang… - Microbiology …, 2023 - Am Soc Microbiol
Hypermucoviscosity is a hallmark of hypervirulent Klebsiella pneumoniae (hvKP). However,
the molecular basis of its regulation is largely unknown. We hypothesize that …

[HTML][HTML] Salmonella enterica relies on carbon metabolism to adapt to agricultural environments

M Han, J Schierstaedt, Y Duan, M Nietschke… - Frontiers in …, 2023 - frontiersin.org
Salmonella enterica, a foodborne and human pathogen, is a constant threat to human
health. Agricultural environments, for example, soil and plants, can be ecological niches and …