Limiting the availability of key angiogenesis‐promoting factors is a successful strategy to
ablate tumor‐supplying blood vessels or to reduce excessive vasculature in diabetic …

Hypothesis The selective permeation of molecules and nanomedicines across the diseased
vasculature dictates the success of a therapeutic intervention. Yet, in vitro assays cannot …

Abstract Organ-on-a-chip (OOAC) has attracted great attention during the last decade as a
revolutionary alternative to conventional animal models. This cutting-edge technology has …

Cardiovascular disease is the cause of death in≈ 50% of hemodialysis patients.
Accumulation of uremic solutes in systemic circulation is thought to be a key driver of the …

Cardiovascular diseases (CVDs) have been one of the major causes of human deaths in the
world. The study of CVDs has focused on cell chemotaxis for decades. With the advances in …

The microvasculature is an essential component of nearly all tissues, with most cells
residing within 200 μm of a vessel. Endothelial cells form the inner wall of microvessels and …

Fiber-shaped materials have great potential for tissue engineering applications as they
provide structural support and spatial patterns within a three-dimensional construct. Here we …

Polarity is critical for development and tissue-specific function. However, the acquisition and
maintenance of tissue polarity is context dependent. Thus, cell and tissue polarity depend on …

Vascular pathologies are prevalent in a broad spectrum of diseases, necessitating a deeper
understanding of vascular biology, particularly in overcoming the oxygen and nutrient …

Perfusable vascularization of tissue-engineered systems remains one of the main hurdles in
producing large-scale functional tissues. Blood vessel formation by endothelial cells is …