Patients with Alagille syndrome carry monogenic mutations in the Notch signaling pathway
and face complications such as jaundice and cholestasis. Given the presence of intrahepatic …

N‐cadherin is a homophilic cell‐cell adhesion molecule that plays a critical role in
maintaining vascular stability and modulating endothelial barrier permeability. Pre‐clinical …

Vessels pervade almost all body tissues, and significantly influence the pathophysiology of
human body. Previous attempts to establish multi-scale vascular connection and function in …

Tissue engineering is an interdisciplinary approach that combines engineering, material,
and biomedical science with purposes to regenerate damaged tissues by fusing the body …

Pericytes are mural cells that play an important role in regulation of angiogenesis and
endothelial function. Cadherins are a superfamily of adhesion molecules mediating Ca2+ …

In the human body, blood flows from the heart to organs and tissues through a hierarchical
vascular tree, consisting of large arteries that branch into arterioles and further into …

The directed or de novo formation of microvasculature in engineered tissue constructs is
essential for accurately replicating physiological function. A limiting factor of a system relying …

In this study we produced a set of in vitro culture platforms to model vascular cell responses
to growth factors and factor delivery vehicles. Two of the systems (whole vessel and whole …

A wide range of conditions, including chronic inflammatory diseases and cancer, are
characterized by the fibrotic microarchitecture and increased stiffness of collagen type I …

The development of adequate experimental models is crucial to furthering the current
mechanistic understanding of the etiopathogenesis, subsequent growth, and ultimate …