[HTML][HTML] Vascular tissue engineering: progress, challenges, and clinical promise
Although the clinical demand for bioengineered blood vessels continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging …
options for vascular conduits remain limited. The synergistic combination of emerging …
N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer
In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-
cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of …
cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of …
Integration of substrate-and flow-derived stresses in endothelial cell mechanobiology
CA Dessalles, C Leclech, A Castagnino… - Communications …, 2021 - nature.com
Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …
that regulate their structure and function in health and disease. Here, we review EC …
Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids
VS Shirure, Y Bi, MB Curtis, A Lezia… - Lab on a Chip, 2018 - pubs.rsc.org
Most cancer treatment strategies target cell proliferation, angiogenesis, migration, and
intravasation of tumor cells in an attempt to limit tumor growth and metastasis. An in vitro …
intravasation of tumor cells in an attempt to limit tumor growth and metastasis. An in vitro …
From arteries to capillaries: approaches to engineering human vasculature
S Fleischer, DN Tavakol… - Advanced functional …, 2020 - Wiley Online Library
From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …
scales and cell types. The convergence of bioengineering, materials science, and stem cell …
Microfabricated blood vessels for modeling the vascular transport barrier
The vascular endothelium forms the inner lining of blood vessels and actively regulates
vascular permeability in response to chemical and physical stimuli. Understanding the …
vascular permeability in response to chemical and physical stimuli. Understanding the …
Microfluidics‐based biomaterials and biodevices
The rapid development of microfluidics technology has promoted new innovations in
materials science, particularly by interacting with biological systems, based on precise …
materials science, particularly by interacting with biological systems, based on precise …
Engineered models to parse apart the metastatic cascade
While considerable progress has been made in studying genetic and cellular aspects of
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …
3D liver tissue model with branched vascular networks by multimaterial bioprinting
X Liu, X Wang, L Zhang, L Sun, H Wang… - Advanced …, 2021 - Wiley Online Library
Complicated vessels pervade almost all body tissues and influence the pathophysiology of
the human body significantly. However, current fabrication strategies have limited success at …
the human body significantly. However, current fabrication strategies have limited success at …
Epstein− Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas
Cancer cells subvert host immune surveillance by altering immune checkpoint (IC) proteins.
Some Epstein− Barr virus (EBV)-associated tumors have higher Programmed Cell Death …
Some Epstein− Barr virus (EBV)-associated tumors have higher Programmed Cell Death …