Dihydrotestosterone is a potent androgen metabolite formed from testosterone by action of
5α-reductase isoenzymes. Mutations in the type 2 isoenzyme cause a disorder of 46, XY sex …

Dihydrotestosterone (DHT) is the most potent natural androgen in humans. There has been
an increasing interest in this androgen and its role in the development of primary and …

abstract Context: In 46, XY disorders of sex development, 5α-reductase deficiency is rare
and is not usually the first-intention diagnosis in newborn ambiguous genitalia, contrary to …

α-Reductase type 2 enzyme catalyzes the conversion of testosterone into
dihydrotestosterone, a potent androgen responsible for male sexual development during the …

Introduction The conversion of testosterone into dihydrotestosterone is catalyzed by the 5α-
reductase type 2 enzyme which plays a crucial role in the external genitalia virilization. It is …

The human chorionic gonadotropin (hCG) test represents a key step in assessing Leydig
cell function in prepubertal males, but differences in terms of hCG doses, number of …

Most of the patients with 5α-RD 2 deficiency are reared in the female social sex due to their
severely undervirilized external genitalia but~ 60% who have not been submitted to …

BACKGROUND 5α-Reductase 2 deficiency (5ARD) is a known cause of 46, XY disorders of
sex development (DSD). Traditionally, the diagnosis relies on dihydrotestosterone (DHT) …

Objective. To evaluate diagnosis, age of referral, karyotype, and sex of rearing of cases with
disorders of sex development (DSD) with ambiguous genitalia. Methods. Retrospective …

The 5α-reductase type 2 enzyme catalyzes the conversion of testosterone into
dihydrotestosterone, playing a crucial role in male development. This enzyme is encoded by …