Global brain inflammation in stroke

K Shi, DC Tian, ZG Li, AF Ducruet, MT Lawton… - The Lancet …, 2019 - thelancet.com
Stroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal
cell death and the release of factors such as damage-associated molecular patterns …

The role of plasminogen activators in stroke treatment: fibrinolysis and beyond

AM Thiebaut, M Gauberti, C Ali… - The Lancet …, 2018 - thelancet.com
Although recent technical advances in thrombectomy have revolutionised acute stroke
treatment, prevalence of disability and death related to stroke remain high. Therefore …

Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: role of mitochondria, inflammation, and reactive oxygen species

S Nair, E Rocha‐Ferreira, B Fleiss… - Journal of …, 2021 - Wiley Online Library
Preclinical studies have shown that mesenchymal stem cells have a positive effect in
perinatal brain injury models. The mechanisms that cause these neurotherapeutic effects …

Neurovascular inflammation and complications of thrombolysis therapy in stroke

Q Liu, K Shi, Y Wang, FD Shi - Stroke, 2023 - Am Heart Assoc
Intravenous thrombolysis via tPA (tissue-type plasminogen activator) is the only approved
pharmacological treatment for acute ischemic stroke, but its benefits are limited by …

When the blood hits your brain: the neurotoxicity of extravasated blood

JA Stokum, GJ Cannarsa, AP Wessell, P Shea… - International Journal of …, 2021 - mdpi.com
Hemorrhage in the central nervous system (CNS), including intracerebral hemorrhage (ICH),
intraventricular hemorrhage (IVH), and aneurysmal subarachnoid hemorrhage (aSAH) …

Immune changes in peripheral blood and hematoma of patients with intracerebral hemorrhage

C Jiang, Y Wang, Q Hu, J Shou, L Zhu… - The FASEB …, 2020 - Wiley Online Library
Immunologic changes in the hematoma of patients with intracerebral hemorrhage (ICH) and
the contribution of these changes to prognosis are unknown. We collected the blood …

Complex clearance mechanisms after intraventricular hemorrhage and rt-PA treatment—A review on clinical trials

B Bosche, P Mergenthaler, TR Doeppner… - Translational stroke …, 2020 - Springer
Intracerebral hemorrhage in combination with intraventricular hemorrhage (IVH) is a severe
type of stroke frequently leading to prolonged clinical care, continuous disability, shunt …

Early inflammatory cytokine expression in cerebrospinal fluid of patients with spontaneous intraventricular hemorrhage

WC Ziai, AR Parry-Jones, CB Thompson, LH Sansing… - Biomolecules, 2021 - mdpi.com
We investigated cerebrospinal fluid (CSF) expression of inflammatory cytokines and their
relationship with spontaneous intracerebral and intraventricular hemorrhage (ICH, IVH) and …

Triad3A-dependent TLR4 ubiquitination and degradation contributes to the anti-inflammatory effects of pterostilbene on vascular dementia

J Xu, J Liu, Y Mi, T Zhao, D Mu, Q Meng… - Journal of agricultural …, 2022 - ACS Publications
Pterostilbene, a methylated stilbene derived from many plant foods, has significant anti-
inflammatory activity. Meanwhile, vascular dementia (VaD) is the second most common …

Should individual timeline and serial CT/MRI panels of all patients be presented in acute brain insult cohorts? A pilot study of 45 patients with decompressive …

AH Autio, J Paavola, J Tervonen, M Lång… - Acta …, 2023 - Springer
Purpose Our review of acute brain insult articles indicated that the patients' individual (i)
timeline panels with the defined time points since the emergency call and (ii) serial brain …